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Anti-MeCP2 antibody produced in rabbit

Name: Anti-MeCP2 antibody produced in rabbit
Brand: SIGMA
Price: 6366.5 SEK

~0.6 mg/mL, affinity isolated antibody, buffered aqueous solution

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Size/SKU	Availability	Price
200 μL	Please contact Customer Service for Availability	7 490,00 kr 6 366,50 kr

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02686372

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

6 366,50 kr

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~75 kDa

species reactivity

human

concentration

~0.6 mg/mL

technique(s)

microarray: suitable, western blot: 0.5-1 μg/mL using nuclear extracts of the MCF7 breast carcinoma cell line.

UniProt accession no.

P51608

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MECP2(4204)
mouse ... Mecp2(17257)
rat ... Mecp2(29386)

Description

General description

Methyl-CpG binding protein 2 (MeCP2) possesses a methyl-CpG-binding domain (MBD) and a transcriptional repression domain.

Immunogen

synthetic peptide corresponding to the C-terminus of human MeCP2 (amino acids 465-478) conjugated to KLH. The sequence is conserved in rat and mouse.

Biochem/physiol Actions

MeCP2 can bind to a single symmetrically methylated CpG pair. It is also capable of binding to chromosomes at sites known to have methylated DNA. MeCP2 silences transcription by recruiting the histone deacetylase (HDAC) repressive machinery via recruitment of the Sin 3A corepressor thus removing acetyl groups from histones and consequently silencing genes.

Methyl-CpG binding protein 2 (MeCP2) has been shown be crucial for brain development. It is part of the methyl-CpG-binding proteins, which are involved in repression of gene expression by binding to methylated DNA. Mutations in the gene encoding MeCP2 have been associated with Rett syndrome (RTT).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M6818	M7443	SAB2101452
Sigma-Aldrich M9317 Anti-MeCP2 antibody produced in rabbit	Sigma-Aldrich M6818 Anti-MeCP2 antibody, Mouse monoclonal	Sigma-Aldrich M7443 Anti-MeCP2 antibody, Mouse monoclonal	Sigma-Aldrich SAB2101452 Anti-MECP2 (ab1) antibody produced in rabbit
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form affinity isolated antibody
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
technique(s) microarray: suitable, western blot: 0.5-1 μg/mL using nuclear extracts of the MCF7 breast carcinoma cell line.	technique(s) immunocytochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.1-0.2 μg/mL using nuclear cell extract of cultured Jurkat, human acute T cell leukemia cells, or cultured MCF7 human breast carcinoma.	technique(s) immunocytochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1-2 μg/test using nuclear extract of cultured human acute T cell leukemia Jurkat cells or MCF7 cells	technique(s) western blot: suitable

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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