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Monoclonal Anti-Neurofilament 160 antibody produced in mouse

Name: Monoclonal Anti-Neurofilament 160 antibody produced in mouse
Brand: SIGMA
Price: 573 USD
Availability: InStock

~2 mg/mL, clone RMO44, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Neurofilament Medium Chain

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Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$573.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01322393

Conjugate:

unconjugated

Clone:

RMO44, monoclonal

Application:

ARR, IHC, WB

Citations:

$573.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RMO44, monoclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat, zebrafish

concentration

~2 mg/mL

technique(s)

immunohistochemistry: suitable, microarray: suitable, western blot: 1-2 μg/mL using extract of SHSy5y human neuroblastoma cells

isotype

IgG1

UniProt accession no.

P07197

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NEFM(4741)
mouse ... Nefm(18040)
rat ... Nefm(24588)

Description

General description

Monoclonal Anti- Neurofilament 160 (mouse IgG1 isotype) is derived from the hybridoma RMO44 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified mid-sized rat neurofilament (NF-M) subunit. Neurofilaments are one of the five major groups of intermediate filaments (Ifs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kDa, 160 kDa and 200 kDa.

Neurofilament 160 (NEFM) is one among the most abundant filaments in post-mitotic neurons.

Immunogen

purified mid-sized rat neurofilament (NF-M) subunit.

Application

Monoclonal Anti-Neurofilament 160 antibody produced in mouse has been used in:

enzyme-linked immunosorbent assay (ELISA)
western blot analysis
immunohistochemistry
antibody labelling

Biochem/physiol Actions

Neurofilament 160 (NEFM) associates with the dopamine receptor.

Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals. These molecules undergo post-translational modifications, which results in their heterogeneity including different levels of phosphorylation. The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing their interaction with cytoplasmic organelles.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	N5264	N2912	AB5735
Sigma-Aldrich N2787 Monoclonal Anti-Neurofilament 160 antibody produced in mouse	Sigma-Aldrich N5264 Monoclonal Anti-Neurofilament 160 antibody produced in mouse	Sigma-Aldrich N2912 Anti-Neurofilament 160/200 antibody, Mouse monoclonal	Sigma-Aldrich AB5735 Anti-Neurofilament M Antibody
description ~2 mg/mL, clone RMO44, purified immunoglobulin, buffered aqueous solution	description clone NN18, ascites fluid	description ~2 mg/mL, clone RMdO20, purified from hybridoma cell culture	description Chemicon^®, from chicken
Gene Information human ... NEFM(4741) mouse ... Nefm(18040) rat ... Nefm(24588)	Gene Information chicken ... NEFM(396206) human ... NEFM(4741) mouse ... Nefm(18040) rat ... Nefm(24588)	Gene Information human ... NEFH(4744), NEFM(4741) mouse ... Nefh(380684), Nefm(18040) rat ... Nefh(24587), Nefm(24588)	Gene Information human ... NEFM(4741) mouse ... Nefm(18040) rat ... Nefm(24588)
species reactivity human, mouse, rat, zebrafish	species reactivity human, pig	species reactivity mouse, rat, human	species reactivity mouse, human, rat
biological source mouse	biological source mouse	biological source mouse	biological source chicken
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone RMO44, monoclonal	clone NN18, monoclonal	clone RMdO20, monoclonal	clone polyclonal
antibody form purified immunoglobulin	antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form purified antibody

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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