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Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit

Name: Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Bcl-2 Binding Component 3, Anti-p53 Upregulated Modulator of Apoptosis

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD04040565

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~23 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

microarray: suitable, western blot: 2-4 μg/mL

UniProt accession no.

Q96PG8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BBC3(27113)

Description

General description

p53 upregulated modulator of apoptosis (PUMA) protein is a member of the B-cell lymphoma 2 (BCL2) family. It is a pro-apoptotic BCL-2 homology 3 (BH3)-only protein and has a small BH3 domain. The PUMA gene is mapped on the human chromosome at 19q13.32.

Immunogen

synthetic peptide corresponding to amino acids 2 to 16 of human PUMA-α.

Application

Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit has been used in western blotting[1] and immunoprecipitation.

Biochem/physiol Actions

p53 upregulated modulator of apoptosis (PUMA) acts as a determinant of the levels of germ cells during ovarian development. It promotes apoptosis in various cellular stress insults. Deletion of the PUMA gene is observed in several kinds of human cancers.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB3500466	SAB3500465	B4436
Sigma-Aldrich P4743 Anti-PUMA/bbc3, N-Terminal antibody produced in rabbit	Sigma-Aldrich SAB3500466 Monoclonal Anti-PUMA antibody produced in mouse	Sigma-Aldrich SAB3500465 Monoclonal Anti-PUMA antibody produced in mouse	Sigma-Aldrich B4436 Anti-53BP1 (C-terminal) antibody produced in rabbit
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form affinity isolated antibody
UniProt accession no. Q96PG8	UniProt accession no. Q9BXH1	UniProt accession no. Q9BXH1	UniProt accession no. Q12888
Gene Information human ... BBC3(27113)	Gene Information human ... BBC3(27113)	Gene Information human ... BBC3(27113)	Gene Information human ... TP53BP1(7158) mouse ... Trp53bp1(27223) rat ... Tp53bp1(296099)

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c