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P4761

Poly-L-glutamic acid sodium salt

mol wt 15,000-50,000

Synonym(s):

L-Glutamic acid homopolymer sodium salt

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Size/SKUAvailabilityPrice
25 mg
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$91.30
100 mg

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$241.00
500 mg

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$658.00
$493.50
1 g

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$1,140.00
$855.00

About This Item

CAS Number:
UNSPSC Code:
12352209
NACRES:
NA.25
MDL number:

$91.30


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form

powder

Quality Segment

mol wt

15,000-50,000

color

white to off-white

application(s)

detection

storage temp.

−20°C

SMILES string

N([C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)[C@@H](N)CCC(=O)O

InChI

1S/C15H23N3O10/c16-7(1-4-10(19)20)13(25)17-8(2-5-11(21)22)14(26)18-9(15(27)28)3-6-12(23)24/h7-9H,1-6,16H2,(H,17,25)(H,18,26)(H,19,20)(H,21,22)(H,23,24)(H,27,28)/t7-,8-,9-/m0/s1

InChI key

BUZMZDDKFCSKOT-CIUDSAMLSA-N

Application


  • Effect of Micelle-Incorporated Cisplatin With Sizes Ranging From 8 to 40 nm for the Therapy of Lewis Lung Carcinoma.: This research explores the use of micelle-incorporated cisplatin nanoparticles for cancer therapy, highlighting the significance of particle size on therapeutic efficacy. Poly-ʟ-glutamic acid sodium salt is used to improve drug delivery and target specificity (Wang Z et al., 2021).

  • Ternary Polypeptide Nanoparticles with Improved Encapsulation, Sustained Release, and Enhanced In Vitro Efficacy of Carfilzomib.: This paper describes the development of ternary polypeptide nanoparticles, including poly-ʟ-glutamic acid sodium salt, to enhance the encapsulation and release of carfilzomib, an anticancer drug. The study demonstrates improved drug efficacy and controlled release profiles (Agbana P et al., 2020).

  • Polymeric Core-Shell Nanoparticles Prepared by Spontaneous Emulsification Solvent Evaporation and Functionalized by the Layer-by-Layer Method.: This research focuses on the preparation of polymeric core-shell nanoparticles using a spontaneous emulsification method. Poly-ʟ-glutamic acid sodium salt is used to functionalize these nanoparticles, which can be applied in drug delivery systems (Szczęch M et al., 2020).

  • Co-administration of Combretastatin A4 Nanoparticles and Sorafenib for Systemic Therapy of Hepatocellular Carcinoma.: This study evaluates the combined use of combretastatin A4 nanoparticles and sorafenib for treating liver cancer. Poly-ʟ-glutamic acid sodium salt is employed to enhance the stability and delivery of these nanoparticles, showing promise in improving therapeutic outcomes (Wang Y et al., 2019).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

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This Item
P4636P1818P3418
description

mol wt 15,000-50,000

description

mol wt 3,000-15,000

description

mol wt 1,500-5,500 by MALLS

description

mol wt 2,000-11,000

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white to off-white

color

white to off-white

color

white to light yellow

color

white to off-white

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

detection

application(s)

-

application(s)

cell analysis

application(s)

-

mol wt

15,000-50,000

mol wt

3,000-15,000

mol wt

1,500-5,500 by MALLS

mol wt

2,000-11,000


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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