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Anti-RER1 antibody produced in rabbit

Name: Anti-RER1 antibody produced in rabbit
Brand: SIGMA
Price: 1010 NZD

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-RER1 retention in endoplasmic reticulum 1

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$1,010.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

$1,010.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~25 kDa

species reactivity

human, rat, mouse

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 1-2 μg/mL using mouse 3T3 and rat NRK cells, western blot: 3-6 μg/mL using whole extract of HEK-293T cells expressing human Rer1

UniProt accession no.

O15258

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RER1(11079)
mouse ... Rer1(67830)
rat ... Rer1(98675)

Description

General description

Retention in endoplasmic reticulum 1 (Rer1p) is found in Golgi-compartment. The protein contains four transmembrane domains (TDMs), with the amino and carboxy termini facing the cytosol and recognizes polar amino acids in TMDs of several proteins including sec12p and sec71p.

Application

Anti-RER1 antibody produced in rabbit has been used in:

immunoblotting
immunohistochemistry
immunofluorescence

Anti-RER1 antibody produced in rabbit may be used in immunoblotting, immunofluorescence and immunohistochemical (IHC) techniques. It is used to determine the roles of RER1 in the retention/retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.

Biochem/physiol Actions

Anti-Rer1 recognizes human, mouse, and rat Rer1.

Retention in endoplasmic reticulum 1 (Rer1) is essential for retrieval of endoplasmic reticulum (ER) membrane proteins from the early Golgi compartment. In addition, mammalian Rer1 is also involved in the ER retention/retrieval of unassembled γsecretase complex subunits. Rer1 interacts with immature nicastrin and unassembled Pen2 through critical residues found in their TMDs. Downregulation of protein expression enhances surface localization of Pen2, whereas Upregulated expression of Rer1 stabilizes unassembled Pen2. Thus, Rer1 regulates the assembly of the γ-secretase complex and therefore contributes to total cellular γ-secretase activity.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA051400	HPA047947	SAB4300183
Sigma-Aldrich R4407 Anti-RER1 antibody produced in rabbit	Sigma-Aldrich HPA051400 Anti-RER1 antibody produced in rabbit	Sigma-Aldrich HPA047947 Anti-PER1 antibody produced in rabbit	Sigma-Aldrich SAB4300183 Anti-phospho-EGFR (pTyr¹¹⁹⁷) antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
species reactivity human, rat, mouse	species reactivity human	species reactivity human	species reactivity mouse, human, rat
form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous solution
Gene Information human ... RER1(11079) mouse ... Rer1(67830) rat ... Rer1(98675)	Gene Information human ... RER1(11079)	Gene Information human ... PER1(5187)	Gene Information human ... EGFR(1956)

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

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