Key Documents

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit

Name: Anti-α1-Syntrophin (RA-16) antibody produced in rabbit
Brand: SIGMA
Price: 472.6 USD
Availability: InStock

buffered aqueous solution, IgG fraction of antiserum

Synonym(s):

Anti-SNTA1

Select a Size

Change View

Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$556.00 $472.60

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03454688

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (f), WB

Citations:

$472.60

List Price$556.00Save 15%

Web-Only Promotion

Available to ship TODAYDetails

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 60 kDa

species reactivity

rat

technique(s)

immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle, microarray: suitable, western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Snta1(20648)
rat ... Snta1(362242)

Description

General description

α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.

Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.

Immunogen

synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.

Application

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.

Biochem/physiol Actions

α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.

α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	M9818	D8168	SAB5701356
$Anti-α1-Syntrophin (RA-16) antibody produced in rabbit buffered aqueous solution, IgG fraction of antiserum$ Sigma-Aldrich S4813 Anti-α1-Syntrophin (RA-16) antibody produced in rabbit	Sigma-Aldrich M9818 Anti-Myopodin antibody produced in rabbit	Sigma-Aldrich D8168 Monoclonal Anti-Dystrophin antibody produced in mouse	Sigma-Aldrich SAB5701356 Anti-Syntrophin alpha 1 antibody produced in rabbit
description buffered aqueous solution, IgG fraction of antiserum	description affinity isolated antibody, buffered aqueous solution	description clone MANDYS8, ascites fluid	description -
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form ascites fluid	antibody form -
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in wet ice
species reactivity rat	species reactivity rat	species reactivity chicken, rat, human, pig, rabbit, mouse	species reactivity rat, mouse, human

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.