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Anti-SynCAM antibody produced in rabbit

Name: Anti-SynCAM antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-IGSF4, Anti-Necl-2, Anti-RAI75, Anti-SgIGSF, Anti-Tslc1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD07370522

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC, WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

mouse, rat

technique(s)

immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde, microarray: suitable, western blot: 0.5-1.0 μg/mL using mouse brain and rat brain extract (S1 fraction)

UniProt accession no.

Q8R5M8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cadm1(54725)
rat ... Cadm1(363058)

Description

General description

Anti-SynCAM is developed in rabbit using a synthetic peptide corresponding to amino acids located at the C-terminus of mouse SynCAM1 conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Synaptic cell adhesion molecule (SynCAM) is a brain-specific protein which has an immunoglobulin domain. It binds to intracellular PDZ-domain protein. SynCAMs have also been called nectin-like molecules (Necls). SynCAM1 is also known as Necl-2/ IGSF4/ RA175/ SgIGSF/ TSLC1. SynCAM contains an N-terminal signal peptide, three extracellular Ig domains, a single transmembrane region and a short C-terminal cytoplasmic domain. It is expressed only in brain and is localized to synapses.

SynCAM proteins consist of a C-terminal cytoplasmic domain, an N-terminal signaling domain and three extracellular immunoglobulin domains.. Anti-SynCAM antibody is specific for SynCAM in mouse and rats. The SynCAM1 immunizing peptide (mouse, amino acids 431-445) specifically inhibits the staining of the SynCAM band in immunoblotting.

Immunogen

This immunogen sequence is identical in human SynCAM1, highly conserved (90%) in the splice variant SynCAM2 and displays limited homology (55%) to SynCAM3.

synthetic peptide corresponding to amino acids 431-445 located at the C-terminus of mouse SynCAM1 conjugated to KLH.

Application

Anti-SynCAM antibody produced in rabbit has been used in:
immunoprecipitation
immunoblotting
immunohistochemistry
immunostaining
immunofluorescence

Biochem/physiol Actions

SynCAM is a neurological cell-adhesion protein that regulates the formation of synapses. Expression of synaptic cell adhesion molecule (SynCAM) in non-neuronal cells induces synaptic formation and affects synaptic function in hippocampal neurons. It functions as a homophilic cell adhesion molecule at the synapse. SynCAM is believed to interact with PDZ-domain synaptic proteins CASK and syntenin via its cytoplasmic tail.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB1411161	SAB4200060	SAB4200186
Sigma-Aldrich S4945 Anti-SynCAM antibody produced in rabbit	Sigma-Aldrich SAB1411161 Anti-CADM3 antibody produced in rabbit	Sigma-Aldrich SAB4200060 Anti-CYLD antibody produced in rabbit	Sigma-Aldrich SAB4200186 Anti-DCLK1 antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
mol wt antigen 48 kDa	mol wt antigen 43.3 kDa	mol wt antigen ~110 kDa	mol wt ~81 kDa

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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