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Anti-STIM1 (C-terminal) antibody produced in rabbit

Name: Anti-STIM1 (C-terminal) antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GOK, Anti-Stromal interaction molecule 1

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IP, WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 90 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

immunoprecipitation (IP): 2.5-5 μg using extracts of rat PC12 cells., indirect immunofluorescence: 2.5-5 μg/mL using human HeLa cells., western blot: 2-4 μg/mL using whole extract of mouse 3T3 cells.

UniProt accession no.

Q13586

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... STIM1(6786)
mouse ... Stim1(20866)
rat ... Stim1(117086)

Description

General description

Stromal interaction molecule 1 (STIM1) is a conserved single-pass transmembrane protein. STIM1 is expressed ubiquitously in a wide variety of human primary and transformed cell types. STIM1 localizes predominantly in the membrane of the endoplasmic reticulum (ER). It contains an N-terminal EF hand motif located in the ER lumen and appears to function as a sensor of ER Ca²⁺ levels.

Immunogen

synthetic peptide corresponding to amino acids 657-683 of human STIM1, conjugated to KLH via an N-terminal residue. The corresponding sequence is identical in rat, mouse, bovine, monkey, and dog.

Application

Anti-STIM1 (C-terminal) antibody produced in rabbit has been used in:

western blot
immunoprecipitation
immunofluorescence
immunohistochemistry

Biochem/physiol Actions

Stromal interaction molecule 1 (STIM1) is required for the activation of store-operated Ca²⁺ influx. STIM1 undergoes rapid oligomerization and redistributes into discrete spots (punctae) that move towards and accumulate in the cell periphery, possibly to activate Orai1 that is located in the plasma membrane. Overexpression of STIM1 and Orai1 together markedly increases the calcium release-activated channels (CRAC) current (I-CRAC). Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex plays a major role in the activation of store-operated calcium (SOC) channel in response to internal Ca²⁺ store depletion.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	P0068	SAB3500365	HPA011088
Sigma-Aldrich S6197 Anti-STIM1 (C-terminal) antibody produced in rabbit	Sigma-Aldrich P0068 Anti-p62/SQSTM1 (C-terminal) antibody produced in rabbit	Sigma-Aldrich SAB3500365 Anti-STIM1 antibody produced in rabbit	Sigma-Aldrich HPA011088 Anti-STIM1 antibody produced in rabbit
description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
species reactivity human, rat, mouse	species reactivity rat, mouse, human	species reactivity human, mouse, rat	species reactivity human

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c