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Anti-SMC6 antibody produced in rabbit

Name: Anti-SMC6 antibody produced in rabbit
Brand: SIGMA
Price: 622 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$622.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$622.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 126 kDa

species reactivity

human, rat (predicted), mouse (predicted)

technique(s)

western blot: 1:250-1:500 using whole cell extract of HEK293-T expressing SMC6

UniProt accession no.

Q96SB8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SMC6(79677)
mouse ... Smc6(67241)
rat ... Smc6l1(313961)

Description

General description

Structural maintenance of chromosomes protein 6 (SCM6) belongs to the structural maintenance of chromosomes family. There are at least six SMC family members that form three heterodimers in specific combinations. SCM6 gene is mapped to human chromosome 2p24.2. Structurally, SCM6 has DNA-binding domains at the N and C termini, a long coiled-coil domain, and a hinge region.

Immunogen

synthetic peptide corresponding to amino acids 766-779 of human SMC6, conjugated to KLH via an N-terminal cysteine residue. This sequence differs by one amino acid in mouse, and by two amino acids in rat.

Application

Anti-SMC6 antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Anti-SMC6 (also known as SMC6L1) specifically recognizes SMC6.

Structural maintenance of chromosomes protein 6 (SCM6) along with SMC5 is mainly involved in the cellular response to DNA damage in yeast as well as humans. The yeast SMC5/6 complex contains several non-SMC elements (NSE), including methyl methanesulfonate-sensitivity protein 21 (MMS21) which sumoylates components of the complex. The SMC5/6 complex is recruited to nuclease-induced double strand breaks(DSBs). This event is crucial for human SMC1/3 cohesion complex recruitment to DSBs. SCM6 is known to interact with the papillomavirus E2 protein. Mitotic aberration and abnormal distribution of topoisomerase IIα are associated with depleted levels of Smc5 and Smc6.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA042733	SAB2701298	WH0079677M1
$Anti-SMC6 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich S7822 Anti-SMC6 antibody produced in rabbit	Sigma-Aldrich HPA042733 Anti-SMC6 antibody produced in rabbit	Sigma-Aldrich SAB2701298 Anti-SMC6 antibody produced in rabbit	Sigma-Aldrich WH0079677M1 Monoclonal Anti-SMC6L1 antibody produced in mouse
description IgG fraction of antiserum, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody, buffered aqueous solution	description clone 2E6, purified immunoglobulin, buffered aqueous solution
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
mol wt antigen 126 kDa	mol wt -	mol wt -	mol wt -
form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous solution	form buffered aqueous solution

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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