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Anti-DVL3 (N-terminal) antibody produced in rabbit

Name: Anti-DVL3 (N-terminal) antibody produced in rabbit
Brand: SIGMA
Price: 453 USD
Availability: InStock

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Enhanced Validation

Synonym(s):

Anti-Dishevelled-3

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$453.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IP, WB

Citations:

$453.00

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Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~95 kDa

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

immunoprecipitation (IP): 2.5-5 μg using HEK-293T cell lysate overexpressing human DVL3, western blot: 0.25-0.5 μg/mL using HEK-293T cell lysates overexpressing human DVL3

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DVL3(1857)

Description

General description

Dishevelled 3 (DVL3) is a phosphoprotein rich in serine and threonine. It is widely expressed in fetal tissues and specifically expressed in various adult tissues. DVL3 gene is mapped to human chromosome 3q27.1

Application

Anti-DVL3 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Anti-DVL3 (N-terminal) specifically recognizes human DVL3.

Dishevelled 3 (DVL3) participates in the wingless-related integration site (Wnt) signaling pathway. It plays a key role in hippocampal neurogenesis regulation. Knockdown of DVL3 has been shown to attenuate the activation of the wnt signaling pathway by Wnt3A. DVL3 functions in redundant pathways with DVL1 and DVL2, and is necessary in normal cardiac, cochlea, and neural tube development in mice. DVL3, like other members of the DVL family, functions upstream of glycogen synthase kinase-3 (GSK3) to modulate the canonical wnt pathway. A frame shift mutation in DVL3 gene is implicated in Robinow syndrome. Allelic variation in the DVL3 gene may be associated with major depressive disorder.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0001857M4	SAB4200007	D3570
Sigma-Aldrich SAB4200008 Anti-DVL3 (N-terminal) antibody produced in rabbit	Sigma-Aldrich WH0001857M4 Monoclonal Anti-DVL3 antibody produced in mouse	Sigma-Aldrich SAB4200007 Anti-DVL3 (C-terminal region) antibody produced in rabbit	Sigma-Aldrich D3570 Anti-DVL1 antibody produced in rabbit
description ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution	description clone 4H2, purified immunoglobulin, buffered aqueous solution	description ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution	description ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution, antigen mol wt ~85 kDa
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
mol wt antigen ~95 kDa	mol wt -	mol wt antigen ~95 kDa	mol wt antigen ~85 kDa
clone polyclonal	clone 4H2, monoclonal	clone polyclonal	clone -
Gene Information human ... DVL3(1857)	Gene Information -	Gene Information -	Gene Information -

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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