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ANTI-TAU (MAPT) Antibody

Name: ANTI-TAU (MAPT) Antibody
Brand: SIGMA
Price: 261 CAD

mouse monoclonal, Tau46

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Size/SKU	Availability	Price
25 μL	Please contact Customer Service for Availability	$261.00
100 μL	Please contact Customer Service for Availability	$701.00
200 μL	Please contact Customer Service for Availability	$1,040.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD07370943

Conjugate:

unconjugated

Clone:

Tau46, monoclonal

Application:

ARR, ELISA (i), IHC, IP, WB

Citations:

$261.00

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Properties

Product Name

Anti-Tau antibody, Mouse monoclonal, clone Tau46, purified from hybridoma cell culture

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

Tau46, monoclonal

form

buffered aqueous solution

species reactivity

bovine, rat, human, mouse

packaging

antibody small pack of 25 μL

concentration

~2 mg/mL

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.5-1 μg/mL using mouse brain extract

isotype

IgG1

UniProt accession no.

P10636

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

Description

General description

Tau (τ), also known as MAPT (microtubule associated protein tau), is encoded by the gene mapped to human chromosome 17q21.3. It is highly expressed in neurons, but is most prominent in axons.

Tau is a family of microtubule-associated proteins thought to regulate the stability and organization of microtubules in neuronal cells. The tau protein family is derived from alternative mRNA splice variants that originate from a single gene, and result in mature proteins that vary in size from 352 to 441 amino acids (45 to 60 kDa). Tau loses microtubule-binding activity and aggregates into paired helical filaments (PHFs) in neurodegenerative disorders. PHFs are the basic structural components of neurofibrillary tangles (NFTs). NFT accumulation correlates with the clinical progression of Alzheimer′s disease. Phosphorylation can affect the functional properties of tau and hyperphosphorylation of tau may result in the loss of tau′s microtubule binding activity and the formation of the insoluble aggregates. Hyperphosphorylation and nonenzymatic glycosylation are posttranslational modifications detected in PHF-tau, and numerous sites of hyperphosphorylation of both normal and PHF-tau have been identified.

Immunogen

bovine Tau.

Application

Anti-Tau antibody, Mouse monoclonal has been used in western blotting.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Mouse monoclonal clone Tau46 anti-Tau antibody is useful in ELISA, immunoblotting, immunogold labeling, immunopreciptation as well as immunohistochemistry. It is used as a probe to determine the presence and roles of Tau protein in the regulation of the stability and organization of microtubules in neuronal cells.

Biochem/physiol Actions

Mouse monoclonal clone Tau46 anti-Tau antibody recognizes bovine, rat, human, and mouse Tau (approx. 45 to 60 kDa). The antibody recognizes a phosphorylation-independent epitope in amino acids 404-441 (human). The antibody recognizes all six isoforms of Tau and may cross react with MAP2 protein.

Tau (τ) plays an essential role in the assembly and maintenance of microtubule structure. Deletion of tau (τ) results in developmental delay and learning disability. The gene expression is associated with the development of Alzheimer′s disease (AD). Genetic variation in τ gene increases the risk of susceptibility to the sporadic tauopathies, progressive supranuclear palsy (PSP) and corticobasal degeneration.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5701266	SAB4501821	SAB4501830
Sigma-Aldrich T9450 Anti-Tau antibody, Mouse monoclonal	Sigma-Aldrich SAB5701266 Anti-Tau antibody produced in rabbit	Sigma-Aldrich SAB4501821 Anti-TAU antibody produced in rabbit	Sigma-Aldrich SAB4501830 Anti-TAU antibody produced in rabbit
description clone Tau46, purified from hybridoma cell culture	description -	description affinity isolated antibody	description affinity isolated antibody
species reactivity bovine, rat, human, mouse	species reactivity human	species reactivity mouse, rat, human	species reactivity human, rat, mouse
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form -	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
clone Tau46, monoclonal	clone monoclonal	clone polyclonal	clone polyclonal
Gene Information human ... MAPT(4137) mouse ... Mapt(17762) rat ... Mapt(29477)	Gene Information human ... MAPT(4137)	Gene Information human ... MAPT(4137)	Gene Information human ... MAPT(4137)

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

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