Key Documents

View All Documentation

Anti-UCP-3 antibody produced in rabbit

Name: Anti-UCP-3 antibody produced in rabbit
Brand: SIGMA
Price: 556 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-SLC25A9

Select a Size

Change View

Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$556.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03097017

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), WB

Citations:

$556.00

Available to ship TODAYDetails

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~34 kDa

species reactivity

human, rat, mouse

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:3,000 using protease-digested sections of human and mouse skeletal muscle., western blot: 1:1,000 using extract of E. coli expressing UCP3

UniProt accession no.

P55916

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... UCP3(7352)
mouse ... Ucp3(22229)
rat ... Ucp3(25708)

Description

General description

Anti-Uncoupling Protein 3 (UCP3) is developed in rabbit using a synthetic peptide corresponding to amino acid residues 254-267 of human UCP3, with N-terminal lysine added, conjugated to keyhole limpet hemocyanin (KLH). The uncoupling proteins (UCPs) are mitochondrial inner membrane proteins which comprises UCP1, 2, 3, 4 and 5. UCP3 displays two forms, a long mature, UCP3L and a short, UCP3S form. UCP3 is preferentially expressed in skeletal muscle and in brown adipose tissue (BAT).

UCP3 is a skeletal muscle protein that functions to uncouple mitochondrial respiration from ATP production. UCP3 regulates fatty acid and energy metabolism. This protein inhibits lipid-induced oxidative stress in the mitochondrial components of heart and skeletal muscle cells. UCP3 may also be involved in the pathogenesis of type 2 diabetes . Anti-UCP-3 antibody is specific for UCP3 in humans, rats and mice and does not react with UCP1 and UCP2. Staining of the UCP3 band by immunoblotting is specifically inhibited with the immunizing peptide.

Immunogen

The corresponding sequence in rat and mouse UCP3 differ by 4 and 3 amino acids, respectively.

synthetic peptide corresponding to human UCP-3 sequence (amino acids 254-267) with N-terminal lysine added, conjugated to KLH.

Application

Anti-UCP-3 antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections at 1:3,000 dilution, using protease-digested sections of human and mouse skeletal muscle). The antibody may also be used in immunoblot (approx. 34 kDa, additional weak bands may be detected in some preparations of brown adipose tissue extracts) and western blot (at 1:1,000 dilution, extract of E. coli expressing UCP3).

Anti-UCP-3 antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Biochem/physiol Actions

The uncoupling proteins (UCPs) are considered as transporters functioning as enzymatic uncouplers of oxidative phosphorylation. They are capable of returning protons pumped by the respiratory chain to the mitochondrial matrix. UCP3 is an active proton transporter, regulated by CoQ (ubiquinone), fatty acids or nucleotides.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	M6444	SAB1404511	HPA072225
Sigma-Aldrich U7757 Anti-UCP-3 antibody produced in rabbit	Sigma-Aldrich M6444 Anti-Mitofusin 2 antibody produced in rabbit	Sigma-Aldrich SAB1404511 Monoclonal Anti-UCP1 antibody produced in mouse	Sigma-Aldrich HPA072225 Anti-UCP3 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description clone 4B7, purified immunoglobulin, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
UniProt accession no. P55916	UniProt accession no. O95140	UniProt accession no. P25874	UniProt accession no. P55916
clone polyclonal	clone polyclonal	clone 4B7, monoclonal	clone polyclonal

Still not finding the right product?

Explore all of our products under Anti-UCP-3 antibody produced in rabbit

— or —

Try our Product Selector Tool to narrow your options

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Key Documents

Skip To

Anti-UCP-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Select a Size

About This Item

$556.00

biological source

Quality Segment

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Gene Information

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Disclaimer

Compare Similar Items

This Item

Still not finding the right product?

Safety Information

Storage Class

wgk

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Questions

Reviews

Active Filters

Key Documents

Skip To

Anti-UCP-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Select a Size

About This Item

U7757-.2ML

$556.00

biological source

Quality Segment

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Gene Information

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Disclaimer

Compare Similar Items

This Item

Still not finding the right product?

Safety Information

Storage Class

wgk

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Questions

Reviews

Active Filters