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A0856

Anti-ATG5 (N-terminal) in Kaninchen hergestellte Antikörper

Name: Anti-ATG5 (N-terminal) in Kaninchen hergestellte Antikörper
Brand: SIGMA
Price: 523 CHF

affinity isolated antibody, PBS solution

Synonym(e):

Anti-APG5, Anti-APG5L, Anti-ASP, Anti-ATG5 autophagy related 5 homolog (S. cerevisiae), Anti-Apoptosis-specific protein, Anti-Autophagy protein 5-like

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Ihnen/SKU	Verfügbarkeit	Preis
200 μL	Warenkorb auf Verfügbarkeit prüfen	CHF 523.00

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09753847

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

CHF 523.00

Warenkorb auf Verfügbarkeit prüfen

Für Ihr Target ist ein rekombinanter, konservierungsmittelfreier Antikörper verfügbar. Probieren Sie ZRB1596

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Technischer Dienst

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Eigenschaften

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

PBS solution

mol wt

antigen ~56 kDa (Atg5-Atg12 complex)

species reactivity

mouse, human, rat

packaging

antibody small pack of 25 μL

technique(s)

western blot: 0.5-1 μg/mL using whole extracts of human K562, rat NRK, and mouse 3T3 cells, immunofluorescence: suitable

UniProt accession no.

Q9H1Y0

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATG5(9474)
mouse ... Atg5(11793)
rat ... Atg5(365601)

Beschreibung

Immunogen

synthetic peptide corresponding to amino acids 2-15 of human ATG5, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in rat and mouse.

Application

Anti-ATG5 (N-terminal) antibody has been used:

in immunoblotting
in immunofluorescence
in western blotting

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Rabbit anti-ATG5 (N-terminal specific) was used for western blot analysis to detect the level of ATG5 in SK-N-MC cells after transduction with an adenovirus expressing a shRNA specific to ATG5.

Rabbit anti-ATG5 has been used for immunofluorescence and chemiluminescent western blot analyses.

Biochem/physiol Actions

Atg5 (Apg5) is a 32 kDa protein that is required for autophagy. Atg5 is covalently modified by Atg12, a ubiquitin-like modifier. The Atg12-Atg5-Atg16 complex thus formed, localizes to autophagosome precursors and regulates autophagosome formation. Studies have reported that Atg5 fragment that is formed by calpain cleavage has pro-apoptotic properties.

Rabbit anti-ATG5 (N-terminal) recognizes human, rat, and mouse Atg5-Atg12 complex.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel	A3231	A2856	A3606
Sigma-Aldrich A0856 Anti-ATG5 (N-terminal) in Kaninchen hergestellte Antikörper	Sigma-Aldrich A3231 Anti-ATG3 in Kaninchen hergestellte Antikörper	Sigma-Aldrich A2856 Anti-ATG7 in Kaninchen hergestellte Antikörper	$Anti-ATG3 (C-terminal) in Kaninchen hergestellte Antikörper IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich A3606 Anti-ATG3 (C-terminal) in Kaninchen hergestellte Antikörper
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form IgG fraction of antiserum
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
species reactivity mouse, human, rat	species reactivity human, mouse, rat	species reactivity rat, human, mouse	species reactivity rat, human, mouse
mol wt antigen ~56 kDa (Atg5-Atg12 complex)	mol wt antigen ~36 kDa	mol wt antigen ~75 kDa	mol wt antigen ~36 kDa

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Lagerklasse

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c