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Anti-ATM antibody,Mouse monoclonal

Name: Anti-ATM antibody,Mouse monoclonal
Brand: SIGMA
Price: 176 USD
Availability: InStock

clone MAT3-4G10/8, purified from hybridoma cell culture

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Synonym(s):

Anti-Ataxia-Telangiectasia Mutated

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Size/SKU	Availability	Price
25 μL	Check Cart for Availability	$176.00
100 μL	Check Cart for Availability	$575.00
200 μL	Check Cart for Availability	$748.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.45

MDL number:

MFCD01321740

Conjugate:

unconjugated

Clone:

MAT3-4G10/8, monoclonal

Application:

ELISA (i), IP, WB

Citations:

$176.00

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Properties

biological source

mouse

Quality Segment

200

recombinant

expressed in mouse cell line

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

MAT3-4G10/8, monoclonal

form

PBS solution

mol wt

antigen ~300 kDa

species reactivity

human, mouse

packaging

antibody small pack of 25 μL

concentration

~2 mg/mL

technique(s)

immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 0.1-0.2 μg/mL using HEK-293T total cel extract

isotype

IgG1

UniProt accession no.

Q13315

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATM(472)
mouse ... Atm(11920)

Description

General description

Monoclonal Anti-ATM (mouse IgG1 isotype) is derived from the hybridoma MAT3-4G10/8 produced by the fusion of mouse myeloma cells (NSO) and splenocytes from BALB/c mice immunized with a peptide.

Immunogen

peptide spanning positions 1967-1988 of mouse ATM containing a cysteine at its NH2 terminus coupled to KLH.

Application

Monoclonal Anti-ATM antibody can be used in immunoblotting , ELISA and immunoprecipitation.

Biochem/physiol Actions

Anti-Ataxia-Telangiectasia Mutated (ATM) is responsible for the activation and stabilization of p53 in response to double-strand break (DSB). ATM phosphorylates p53 directly on Ser15 and concomitantly activates other kinases that phosphorylate the same molecule on additional sites. Furthermore, human homolog of double minute 2 (Hdm2) is phosphorylated by ATM on Ser395 and this phosphorylation inhibits Hdm2-mediated degradation of p53.

Monoclonal Anti-ATM antibody reacts specifically with mouse and human ATM.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M2444	MAB3806	B7405
Sigma-Aldrich A1106 Anti-ATM antibody,Mouse monoclonal	Sigma-Aldrich M2444 Anti-MDC1 antibody, Mouse monoclonal	Sigma-Aldrich MAB3806 Anti-ATM phosphoSer1981 Antibody, clone 10H11.E12	Sigma-Aldrich B7405 Anti-Digoxin−Biotin antibody, Mouse monoclonal
description clone MAT3-4G10/8, purified from hybridoma cell culture	description clone MDC1-50, purified from hybridoma cell culture	description clone 10H11.E12, Chemicon^®, from mouse	description clone DI-22, purified from hybridoma cell culture
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity human, mouse	species reactivity monkey, human	species reactivity mouse, human	species reactivity -
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate biotin conjugate
clone MAT3-4G10/8, monoclonal	clone MDC1-50, monoclonal	clone 10H11.E12, monoclonal	clone DI-22, monoclonal
Gene Information human ... ATM(472) mouse ... Atm(11920)	Gene Information human ... MDC1(9656)	Gene Information human ... ATM(472)	Gene Information -

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Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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