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Anti-Activin A antibody produced in goat

Name: Anti-Activin A antibody produced in goat
Brand: SIGMA
Price: 628 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

Synonym(s):

Activin A Antibody, Anti-Activin A antibody produced in goat

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Size/SKU	Availability	Price
0.1 mg	Available to ship TODAYfromMILWAUKEE	$628.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD02095789

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA, IHC (p), Neutral, WB

Citations:

$628.00

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Properties

biological source

goat

Quality Segment

100

recombinant

expressed in goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL, neutralization: suitable, western blot: 0.1 μg/mL

UniProt accession no.

P08476

application(s)

research pathology

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... INHBA(3624)

Description

General description

Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1.

Immunogen

recombinant human activin A expressed in CHO cells.

Application

Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays.

Anti-Activin A antibody produced in goat has been used in immunohistochemical staining.

Biochem/physiol Actions

Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells.

Physical form

Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	A2066	HPA016843	SAB3600001
Sigma-Aldrich A1594 Anti-Activin A antibody produced in goat	Sigma-Aldrich A2066 Anti-Actin antibody produced in rabbit	Sigma-Aldrich HPA016843 Anti-INHBE antibody produced in rabbit	Sigma-Aldrich SAB3600001 Anti-IGF-1 antibody produced in goat
description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody, lyophilized powder
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source goat	biological source rabbit	biological source rabbit	biological source goat
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
UniProt accession no. P08476	UniProt accession no. P68133	UniProt accession no. P58166	UniProt accession no. -

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c