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A2024

Apramycin sulfate salt

Synonyme(s) :

Nebramycin II

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À vous/RéférenceDisponibilitéPrix
1 g
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111,00 $
5 g
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382,00 $

A propos de cet article

Formule empirique (notation de Hill) :
C21H41N5O11 · xH2SO4
Numéro CAS:
Poids moléculaire :
539.58 (free base basis)
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51281633
EC Number:
265-890-7
MDL number:

111,00 $


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biological source

Streptomyces tenebrarius

Quality Segment

form

powder

color

white to brown

antibiotic activity spectrum

Gram-negative bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

InChI

1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

InChI key

WGLYHYWDYPSNPF-RQFIXDHTSA-N

General description

Chemical structure: aminoglycoside

Application

Apramycin is used to study antibiotic resistance [1][2] as well as protein synthesis translocation-step inhibition in bacteria and prokaryotes.

Biochem/physiol Actions

Apramycin inhibits protein synthesis by blocking translocation. It is also able to bind to the eukaryotic decoding site.[3] At low concentrations it inhibits elongation and induces misreading of mRNA during protein synthesis.[4]

Packaging

1G, 5G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.

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Cet article
A2324T1783P9297
description

-

description

aminoglycoside antibiotic

description

aminoglycoside antibiotic

description

≥98% (TLC)

antibiotic activity spectrum

Gram-negative bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

antibiotic activity spectrum

Gram-negative bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, parasites

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

biological source

Streptomyces tenebrarius

biological source

synthetic

biological source

Streptomyces tenebrarius

biological source

-


pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges



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Certificats d'analyse (COA)

Lot/Batch Number

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Questions

1–3 of 3 Questions  
  1. What is the active fraction of Apramycin in Apramycin sulfate salt (A2024-1G)?

    1 answer
    1. The assay specification for this product is ≥450 µg/mg, indicating that 1 mg of dry material contains at least 450 µg of apramycin sulfate salt. The amount of sulfate varies between batches, so an exact value or specification for apramycin cannot be provided. Each batch also contains some water, as noted on the Certificate of Analysis, which must be considered when weighing the product. The total of all other substances is, according to the Certificate of Analysis, ≤15%.

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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