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A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

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Taglio della confezioneSKUDisponibilitàPrezzo
250 μg
Per conoscere la disponibilità, visualizza il carrello
CHF 156.00
1 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 469.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C45H81N13O14S
Numero CAS:
Peso molecolare:
1060.27
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
powder
Assay:
≥95% (HPLC)

CHF 156.00


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Quality Level

assay

≥95% (HPLC)

form

powder

UniProt accession no.

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O

InChI

1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)

InChI key

IDGOADDOQWKZOX-UHFFFAOYSA-N

Gene Information

human ... APP(351)

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Questo articolo
A5080A2326A7973
assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥80% (HPLC)

form

powder

form

powder

form

powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

Amyloid β precursor protein (APP) is a type-1 transmembrane protein.[1] APP is expressed widely and mainly found in the synapses and neurons.[2] The APP gene is mapped to human chromosome 21q21.3.[3]

Application

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.[4]

Biochem/physiol Actions

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques[1] which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis.[2][1] Amyloid β-Protein Fragment 35-25 is an inactive control.

Other Notes

The N—C inverted sequence of fragment 25-35

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP
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The amyloid β-peptide (Aβ) is transported across the blood-brain barrier (BBB) by binding with the receptor for advanced glycation end products (RAGE). Previously, we demonstrated that the Aβ fraction 25-35 (Aβ25-35) increases RAGE expression in the rat hippocampus, likely contributing
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Numero articolo commerciale globale

SKUGTIN
A2201-250UG04061833379318
A2201-1MG04061833349779

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