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A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

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250 μg

Available to ship TODAYfromMILWAUKEE

$185.00
1 mg

Available to ship TODAYfromMILWAUKEE

$554.00
$470.90

About This Item

Empirical Formula (Hill Notation):
C45H81N13O14S
CAS Number:
147740-73-6
Molecular Weight:
1060.27
NACRES:
NA.32
PubChem Substance ID:
24890634
UNSPSC Code:
51111800
MDL number:
MFCD00214225
Form:
powder
Assay:
≥95% (HPLC)

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Quality Level

200

assay

≥95% (HPLC)

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O

InChI

1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)

InChI key

IDGOADDOQWKZOX-UHFFFAOYSA-N

Gene Information

human ... APP(351)

General description

Amyloid β precursor protein (APP) is a type-1 transmembrane protein.[1] APP is expressed widely and mainly found in the synapses and neurons.[2] The APP gene is mapped to human chromosome 21q21.3.[3]

Application

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.[4]

Biochem/physiol Actions

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques[1] which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis.[2][1] Amyloid β-Protein Fragment 35-25 is an inactive control.

Other Notes

The N—C inverted sequence of fragment 25-35

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Amyloid β-Protein Fragment 35-25 ≥95% (HPLC)

Sigma-Aldrich

A2201

Amyloid β-Protein Fragment 35-25

Amyloid β Protein Fragment 1-42

Sigma-Aldrich

A9810

Amyloid β Protein Fragment 1-42

Amyloid β-Protein Fragment 17-28 ≥90% (HPLC), lyophilized powder

Sigma-Aldrich

A4723

Amyloid β-Protein Fragment 17-28

Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)

Sigma-Aldrich

A4559

Amyloid β-Protein Fragment 25-35

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

lyophilized powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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SLCC5834
SLBV2580
SLBS1693V
SLBJ6713V
071M8711

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Jasmine Chebli et al.
Scientific reports, 11(1), 19115-19115 (2021-09-29)
Amyloid precursor protein (APP) is expressed in many tissues in human, mice and in zebrafish. In zebrafish, there are two orthologues, Appa and Appb. Interestingly, some cellular processes associated with APP overlap with cilia-mediated functions. Whereas the localization of APP
Anatoliy I Yashin et al.
Mechanisms of ageing and development, 196, 111477-111477 (2021-04-03)
Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possibility that
Alzheimer's disease: amyloid beta-peptide antibody vaccine as plaque remover.
A Kumar
Journal of biosciences, 25(4), 315-316 (2000-12-20)
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Global Trade Item Number

SKUGTIN
A2201-250UG04061833379318
A2201-1MG04061833349779

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