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A2846

A-134974 dihydrochloride hydrate

≥98% (HPLC), solid

Synonym(s):

N7-[(1′R,2′S,3′R,4′S)-2′,3′-dihydroxy-4′-aminocyclopentyl]-4-amino-5-iodopyrrolopyrimidine dihydrochloride hydrate

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Pack SizeSKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
€321.00
€272.85

About This Item

Empirical Formula (Hill Notation):
C11H14IN5O2 · 2HCl · xH2O
CAS Number:
1049737-44-1
Molecular Weight:
448.09 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24890697
UNSPSC Code:
12352200
MDL number:
MFCD08692561
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

off-white to light tan

solubility

H2O: soluble

originator

Abbott

SMILES string

O.Cl.Cl.N[C@H]1C[C@H]([C@H](O)[C@@H]1O)n2cc(I)c3c(N)ncnc23

InChI

1S/C11H14IN5O2.2ClH.H2O/c12-4-2-17(6-1-5(13)8(18)9(6)19)11-7(4)10(14)15-3-16-11;;;/h2-3,5-6,8-9,18-19H,1,13H2,(H2,14,15,16);2*1H;1H2/t5-,6+,8+,9-;;;/m0.../s1

InChI key

INMLNTBMPNIKQK-HWZUHWJPSA-N

Biochem/physiol Actions

A-134974 is a novel and selective adenosine kinase (AK) inhibitor with IC50 = 60 pM. Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED50= 1 μmol/kg) and at higher doses, reduced locomotor activity (ED50 = 16 μmol/kg). Administration of A-134974 intrathecally (i.t.) was more potent (ED50= 6 nmol) at producing antihyperalgesia than delivering the compound by intracerebralventricular (ED50 = 100 nmol, i.c.v.) or intraplantar (ED50 >300 nmol) routes. In contrast, i.c.v. administration of A-134974 was more effective in reducing locomotor activity than i.t. administration (ED50 values were 1 and >100 nmol, respectively). Increasing the pretreatment time for i.t.-delivered A-134974 caused a greater reduction in locomotor activity (ED50= 10 nmol). This was due to diffusion of A-134974 (i.t.) to supraspinal sites. These data demonstrate that the novel AK inhibitor A-134974 potently reduces thermal hyperalgesia primarily through interactions with spinal sites, whereas its ability to depress locomotor activity is predominantly mediated by supraspinal sites.
A-134974 is a novel and selective adenosine kinase inhibitor. In a rat model of neuropathic pain, intraperitoneal A-134974 reduced tactile allodynia and hyperalgesia in a dose-dependent manner (IC50 = 60 pM).

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under license from Abbott Laboratories.

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This Item
SML1229SML147854764
A-134974 dihydrochloride hydrate ≥98% (HPLC), solid

Sigma-Aldrich

A2846

A-134974 dihydrochloride hydrate

2′,3′-cGAMP sodium salt ≥98% (HPLC)

Sigma-Aldrich

SML1229

2′,3′-cGAMP sodium salt

Ophiobolin A ≥95% (HPLC)

Sigma-Aldrich

SML1478

Ophiobolin A

Neoxanthin ≥90% (HPLC)

Sigma-Aldrich

54764

Neoxanthin

form

solid

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: soluble

solubility

-

solubility

-

solubility

-

storage condition

desiccated

storage condition

-

storage condition

protect from light

storage condition

-

color

off-white to light tan

color

white to beige

color

white to beige

color

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
114M4618V
049K46141
049K4614
077K46042
077K46041

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Articles

Adenosine Receptors

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Global Trade Item Number

SKUGTIN
A2846-5MG04061832433769

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