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A3262

Adenosine 3′,5′-cyclic monophosphate tris salt

≥97% (HPLC), synthetic, powder

Synonym(s):

cAMP, cyclic AMP

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Pack SizeSKUAvailabilityPrice
500 mg
Please contact Customer Service for Availability
€326.00

About This Item

Empirical Formula (Hill Notation):
C10H12N5O6P · C4H11NO3
CAS Number:
102029-77-6
Molecular Weight:
450.34
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
329770822
NACRES:
NA.51
MDL number:
MFCD00058346
Assay:
≥97% (HPLC)
Biological source:
synthetic
Form:
powder
Solubility:
H2O: 100 mg/mL
Storage temp.:
−20°C

€326.00

Please contact Customer Service for Availability
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Product Name

Adenosine 3′,5′-cyclic monophosphate tris salt, ≥97% (HPLC), powder

biological source

synthetic

Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

solubility

H2O: 100 mg/mL

storage temp.

−20°C

SMILES string

NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1

InChI key

CLDDYJFNXTUHIN-MCDZGGTQSA-N

General description

Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays. Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production. Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.

Application

Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture and induced neural stem cells (iNSCs). It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

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Adenosine 3′,5′-cyclic monophosphate tris salt ≥97% (HPLC), powder

Sigma-Aldrich

A3262

Adenosine 3′,5′-cyclic monophosphate tris salt

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Sigma-Aldrich

A9376

Adenosine 2′:3′-cyclic monophosphate sodium salt

Adenosine 3′-monophosphate sodium salt from yeast

Sigma-Aldrich

A0386

Adenosine 3′-monophosphate sodium salt

Adenosine 3′,5′-cyclic monophosphate ≥98.5% (HPLC), powder

Sigma-Aldrich

A9501

Adenosine 3′,5′-cyclic monophosphate

biological source

synthetic

biological source

synthetic (organic)

biological source

yeast

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥97% (HPLC)

assay

≥93%

assay

≥98% (HPLC)

assay

≥98.5% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

white

color

-

color

-

color

white

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000425160
0000425160
0000364881
0000364881
SLCF8554

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Cyclic AMP: master regulator of innate immune cell function
Serezani CH, et al.
American Journal of Respiratory Cell and Molecular Biology, 39(2), 127-132 (2008)
Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors
Tang X, et al.
Stem Cell Research, 16(2), 236-242 (2016)
Yanmin Chen et al.
Planta medica, 85(9-10), 738-744 (2019-06-12)
Chronic heart failure is the terminal stage of various cardiovascular diseases. Despite the availability of several classes of drugs, there is still an unmet need for effective treatment. Based on bench work during the past two decades, we have proposed
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Global Trade Item Number

SKUGTIN
A3262-500MG04061833360545

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