Principaux documents

Voir toute la documentation

Passer à

A3356

Anti-Beta (β)-Amyloid antibody

Name: Anti-Beta (β)-Amyloid antibody
Brand: SIGMA
Price: 611 EUR

rabbit polyclonal

Synonyme(s) :

Anti-A4 AMYLOID PROTEIN, Anti-ABETA, Anti-ABPP, Anti-AD1, Anti-AMYLOID BETA A4, Anti-AMYLOID-BETA PROTEIN (ABP), Anti-APPI

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

Changer de vue

À vous/Référence	Disponibilité	Prix
200 μL	Vérifier la disponibilité des articles du panier	611,00 €

A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), WB

Citations:

611,00 €

Vérifier la disponibilité des articles du panier

Un anticorps recombinant, sans conservateur, est disponible pour votre cible. Essayez ZMS1012

Demander une commande sur mesure

Service technique

Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.

Laissez-nous vous aider

Propriétés

Nom du produit

Anti-β−Amyloid [22-35] antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~4 kDa

species reactivity

rat, human, mouse

packaging

antibody small pack of 25 μL

technique(s)

indirect ELISA: 0.2-0.4 μg/mL using β-amyloid peptide (22-35), western blot: 0.25-0.5 μg/mL using β-amyloid peptide (1-40)

UniProt accession no.

P05067

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)
mouse ... App(11820)
rat ... App(54226)

Description

General description

Rabbit anti-β-amyloid (22-35) antibody specifically recognizes β-amyloid (22-35), β-amyloid (25-35), β-amyloid (1-40) and β-amyloid (1-42) and does not react with β-amyloid (32-35) and β-amyloid (35-25) by ELISA. The antibody detects β-amyloid (1-40) by immunoblotting (approx. 4kDa). Staining of the β-amyloid (1-40) band in immunoblotting is specifically inhibited by the immunizing peptide.

Cleavage of the amyloid precursor protein (APP) by γ-secretase produces the small fragment amyloid β (Aβ) peptide. Cleavage of APP occurs mostly at residue 40 but to a lesser extent residue 42. The amyloid β peptide contains a ~100 kDa soluble N-terminal fragment, and intracellular C-terminal fragments (CTFs) bearing the complete Aβ domain.

Proteolytic cleavage of the amyloid precursor protein (APP) produces the small fragment amyloid β peptide. Cleavage of APP occurs mostly at residue 40 but to a lesser extent residue 42. Aggregates of amyloid β peptide are found deposited in the brains of Alzheimer′s patients.

Immunogen

synthetic peptide corresponding to amino acids 22-35 of human β-amyloid (1-40) fragment, conjugated to KLH. This sequence corresponds to amino acids 693-706 of the human amyloid precursor protein APP, and is identical in mouse and rat APP.

Application

Rabbit anti-β-amyloid (22-35) antibody can be used for ELISA at a concentration of 0.2-0.4μg/mL using β-amyloid peptide (22-35). The product can also be used for western blot at 0.25-0.5μg/mL using β-amyloid peptide (1-40).

Anti-β-Amyloid (22-35) antibody produced in rabbit has been used in:

western blot
dot-blot assay
indirect enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

Secreted Aβ lead to synaptic and neuritic compromise and glial activation. Aggregates of amyloid β peptide are found deposited in the brains of Alzheimer′s patients. Aβ(25-35) and Aβ(22-35) fragments are highly toxic segments of β-amyloid peptides that promote inflammatory processes in astrocytes and fibrillary aggregation of Aβ, thus representing a promising therapeutic target for Alzheimer′s.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 1

Cet article	A8978	A8354	A8717
Sigma-Aldrich A3356 Anti-β−Amyloid [22-35] antibody produced in rabbit	Sigma-Aldrich A8978 Anti-β-Amyloid (13-28) antibody, Mouse monoclonal	Sigma-Aldrich A8354 Anti-β-Amyloid antibody, Mouse monoclonal	$Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich A8717 Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description clone BAM90.1, purified from hybridoma cell culture	description clone NAB 228, purified from hybridoma cell culture	description IgG fraction of antiserum, buffered aqueous solution
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... APP(351) mouse ... App(11820) rat ... App(54226)	Gene Information human ... APP(351)	Gene Information human ... APP(351)	Gene Information human ... APP(351) mouse ... App(11820) rat ... App(54226)
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

Still not finding the right product?

Explore all of our products under Anti-β−Amyloid [22-35] antibody produced in rabbit

— ou —

Essayez notre Outil de sélection de produits pour affiner vos choix.

Classe de stockage

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c