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Anti-ApoER2 antibody produced in rabbit

Name: Anti-ApoER2 antibody produced in rabbit
Brand: SIGMA
Price: 716 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Enhanced Validation

Synonym(s):

Anti-Apolipoprotein E Receptor 2, Anti-LRP8, Anti-Low Density Lipoprotein Receptor-Related Protein 8

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$716.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$716.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~105 kDa

species reactivity

human

enhanced validation

recombinant expression
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technique(s)

western blot: 0.5-1 μg/mL using HEK-293T cells expressing human ApoER2

UniProt accession no.

Q14114

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRP8(7804)

Description

General description

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) is expressed predominantly in the brain and placenta. This gene is located on human chromosome 1p32.

The low-density lipoprotein receptor-related protein 8 (LRP8) or ApoER2 is a member of the LDL receptor family which includes LDLR and VLDLR. These proteins are involved in the uptake of lipid rich proteins into cells and cell signaling. ApoER2 assists in endocytosis and signal transduction.

Immunogen

synthetic peptide corresponding to amino acids 928-945 located near the C-terminus of human ApoER2, conjugated to KLH. This sequence is identical in mouse ApoER2.

Application

Anti-ApoER2 antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) play an important role in the endocytosis of plasma lipoproteins, including ApoE and cholesterol metabolism. In the central nervous system, ApoER2 mediates various neuronal signaling mechanisms during neuronal development, affecting neurite outgrowth, synapse formation and neuronal migration, and neuronal survival in response to acute damage. ApoER2 plays a central role in the reelin/Dab1 signaling pathway that controls neuronal positioning during brain development as well as long-term potentiation (LTP) in the adult brain.

Rabbit anti-ApoER2 antibody recognizes human ApoER2 by immunoblotting (approx. 105kDa). Staining of the ApoER2 band in immunoblotting is specifically inhibited by the ApoER2 immunizing peptide.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB1306331	SAB5702786	WH0007804M1
Sigma-Aldrich A3481 Anti-ApoER2 antibody produced in rabbit	$ANTI-APOER2 (LRP8)(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB1306331 ANTI-APOER2 (LRP8)(C-TERMINAL) antibody produced in rabbit	Sigma-Aldrich SAB5702786 Anti-ApoER2/LRP8 Antibody, clone 0V1R8, Rabbit Monoclonal	Sigma-Aldrich WH0007804M1 Monoclonal Anti-LRP8 antibody produced in mouse
description affinity isolated antibody, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description -	description clone 3H2, purified immunoglobulin, buffered aqueous solution
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form IgG fraction of antiserum	antibody form -	antibody form purified immunoglobulin
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in dry ice
UniProt accession no. Q14114	UniProt accession no. Q14114	UniProt accession no. Q14114	UniProt accession no. Q14114

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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