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A3734

1-Azakenpaullone

≥97% (HPLC), glycogen synthase kinase 3β (GSK3β) inhibitor, powder

Synonym(s):

9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one

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Size/SKUAvailabilityPrice
1 mg
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$162.00
5 mg
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$614.00
$521.90

About This Item

Empirical Formula (Hill Notation):
C15H10BrN3O
CAS Number:
Molecular Weight:
328.16
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
protect from light

$162.00


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Product Name

1-Azakenpaullone, ≥97% (HPLC)

Quality Segment

assay

≥97% (HPLC)

form

powder

storage condition

protect from light

color

gray-brown

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1

InChI

1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)

InChI key

NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Biochem/physiol Actions

1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs.
1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs. 1-Azakenpaullone can be used together with BIO and CHIR99021 as "gold standards" for GSK3 inhibition.
1-Azakenpaullone (AZP) can stimulate the transcription of β-catenin-related genes. This compound can induce the multiplication and replication of β cell.

Disclaimer

air sensitive

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This Item
422000K3888
description

≥97% (HPLC)

description

A potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (IC50 = 230 nM), Lck (IC50= 470 nM), and cyclin-dependent kinases (Cdks).

description

≥98%

form

powder

form

solid

form

solid

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98%

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

protect from light

storage condition

OK to freeze, protect from light

storage condition

-

solubility

DMSO: >10 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 18 mg/mL, clear, yellow


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Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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