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A4559

Amyloid β-Protein Fragment 25-35

≥97% (HPLC)

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250 μg

Available to ship TODAYfromMILWAUKEE

$98.30
1 mg

Available to ship TODAYfromMILWAUKEE

$247.00

About This Item

Empirical Formula (Hill Notation):
C45H81N13O14S
CAS Number:
131602-53-4
Molecular Weight:
1060.27
NACRES:
NA.32
PubChem Substance ID:
24890880
UNSPSC Code:
12352202
MDL number:
MFCD00133076
Form:
powder
Assay:
≥97% (HPLC)

$98.30

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Quality Level

200

assay

≥97% (HPLC)

form

powder

composition

Protein Content, ≥80%

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O

InChI

1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)

InChI key

WIHBNMPFWRHGDF-UHFFFAOYSA-N

Gene Information

human ... APP(351)

General description

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1−40) peptides. It has a β-sheet and β-turn structure.[1]

Application

Amyloid β-Protein Fragment 25-35 has been used:
  • to induce neurotoxicity in cortical cultures
  • to induce Alzheimer′s disease in rat model
  • to induce apoptosis in mesenchymal stem cells (MSCs)

Biochem/physiol Actions

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease.[1] It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

Other Notes

Lyophilized from 0.1% TFA in H2O

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This Item
A2201A4723A9810
Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)

Sigma-Aldrich

A4559

Amyloid β-Protein Fragment 25-35

Amyloid β-Protein Fragment 35-25 ≥95% (HPLC)

Sigma-Aldrich

A2201

Amyloid β-Protein Fragment 35-25

Amyloid β-Protein Fragment 17-28 ≥90% (HPLC), lyophilized powder

Sigma-Aldrich

A4723

Amyloid β-Protein Fragment 17-28

Amyloid β Protein Fragment 1-42

Sigma-Aldrich

A9810

Amyloid β Protein Fragment 1-42

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥95% (HPLC)

form

powder

form

powder

form

lyophilized powder

form

powder

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Lot/Batch Number
0000453548
0000453548
0000375899
0000375899
0000285279

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Conformations and biological activities of amyloid beta peptide 25-35
Millucci L, et al.
Current Protein and Peptide Science, 11(1), 54-67 (2010)
MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model
Han L, et al.
Frontiers in Neuroscience, 12 (2018)
RKIP-Mediated NF-kappaB Signaling is involved in ELF-MF-mediated improvement in AD rat
Zuo H, et al.
International Journal of Molecular Sciences, 15(14), 1658-1658 (2018)
View All Related Papers

Global Trade Item Number

SKUGTIN
A4559-250UG04061833374665
A4559-1MG04061838443540

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