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A4559

Amyloid β-Protein Fragment 25-35

≥97% (HPLC)

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À vous/RéférenceDisponibilitéPrix
250 μg
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104,00 €
1 mg

Disponible dès aujourd'huiDeSt QuentinFallavier

290,00 €

A propos de cet article

Formule empirique (notation de Hill) :
C45H81N13O14S
Numéro CAS:
131602-53-4
Poids moléculaire :
1060.27
NACRES:
NA.32
PubChem Substance ID:
24890880
UNSPSC Code:
12352202
MDL number:
MFCD00133076
Form:
powder
Assay:
≥97% (HPLC)

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Quality Segment

200

assay

≥97% (HPLC)

form

powder

composition

Protein Content, ≥80%

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O

InChI

1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)

InChI key

WIHBNMPFWRHGDF-UHFFFAOYSA-N

Gene Information

human ... APP(351)

General description

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1−40) peptides. It has a β-sheet and β-turn structure.[1]

Application

Amyloid β-Protein Fragment 25-35 has been used:
  • to induce neurotoxicity in cortical cultures
  • to induce Alzheimer′s disease in rat model
  • to induce apoptosis in mesenchymal stem cells (MSCs)

Biochem/physiol Actions

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease.[1] It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Cet article
A5080A2201A1075
Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)

Sigma-Aldrich

A4559

Amyloid β-Protein Fragment 25-35

Amyloid β-Protein Fragment 22-35 ≥95% (HPLC)

Sigma-Aldrich

A5080

Amyloid β-Protein Fragment 22-35

Amyloid β-Protein Fragment 35-25 ≥95% (HPLC)

Sigma-Aldrich

A2201

Amyloid β-Protein Fragment 35-25

Amyloid β Protein Fragment 1-40 ≥90% (HPLC), powder

Sigma-Aldrich

A1075

Amyloid β Protein Fragment 1-40

description

≥97% (HPLC)

description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥90% (HPLC), powder

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

UniProt accession no.

P05067

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Gene Information

human ... APP(351)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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