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A5486

Azoxymethane

13.4 M, ≥98%

Synonym(s):

AOM

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Pack SizeSKUAvailabilityPrice
25 mg

Estimated to ship onMay 07, 2027fromMILWAUKEE

$486.00
100 mg
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$1,480.00

About This Item

Linear Formula:
CH3N=N(→O)CH3
CAS Number:
25843-45-2
Molecular Weight:
74.08
NACRES:
NA.25
PubChem Substance ID:
329770827
UNSPSC Code:
12352124
MDL number:
MFCD00126912
Assay:
≥98%
Form:
liquid
Quality level:
200
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)

$486.00

Estimated to ship onMay 07, 2027Details

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Quality Level

200

assay

≥98%

form

liquid

composition

methylene chloride, ≤1%

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

13.4 M

color

colorless

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

application(s)

genomic analysis

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

General description

Azoxymethane (AOM) is a potent laboratory chemical used to study cancer initiation, progression, and prevention, particularly in the colon. It acts as both a carcinogen, triggering tumor formation, and a gene mutation agent, causing specific alterations in DNA.

Application

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

Biochem/physiol Actions

Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.

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This Item
118502344906409081
Azoxymethane 13.4 M, ≥98%

Sigma-Aldrich

A5486

Azoxymethane

ATM Kinase Inhibitor InSolution, ≥95%

Sigma-Aldrich

118502

ATM Kinase Inhibitor

FURA 2/AM in Solution

Sigma-Aldrich

344906

FURA 2/AM in Solution

Poly(acrylamide-co-diallyldimethylammonium chloride) solution 10 wt. % in H2O

Sigma-Aldrich

409081

Poly(acrylamide-co-diallyldimethylammonium chloride) solution

assay

≥98%

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

form

liquid

form

liquid

form

liquid

form

viscous liquid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

-

color

colorless

color

-

color

-

color

-

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C

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Certificates of Analysis (COA)

Lot/Batch Number
0000515941
0000515941
0000503884
0000503882
0000503882

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Product Information Sheet - A5486

Instructions

Sonia Leon-Cabrera et al.
Cancers, 10(9) (2018-09-22)
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor⁻stroma interactions, and
Carlotta Tacconi et al.
Cancer research, 79(16), 4196-4210 (2019-06-27)
Colorectal cancer is a major cause of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LV) and tumor-associated macrophages (TAM). The VEGFC/VEGFR3 pathway is regarded as the principal inducer of lymphangiogenesis and it contributes
Qifan Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4779-4782 (2014-10-17)
Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense
View All Related Papers

Global Trade Item Number

SKUGTIN
A5486-100MG04061837839597
A5486-25MG04061837839603

Questions

1–10 of 11 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 answer

    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

      Helpful?

  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 answer

    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

      Helpful?

  5. Is Axozymethane volatile?

    1 answer

    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

      Helpful?

  6. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    1 answer

    1. Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

      Helpful?

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 answer

    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  10. How does azoxymethane act to cause cancers?

    1 answer

    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

      Helpful?

1–10 of 11 Questions  

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