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Monoclonal Anti-c-Abl antibody produced in mouse

Name: Monoclonal Anti-c-Abl antibody produced in mouse
Brand: SIGMA
Price: 587 USD
Availability: InStock

clone ABL-148, ascites fluid

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$587.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.44

MDL number:

MFCD00239646

Conjugate:

unconjugated

Clone:

ABL-148, monoclonal

Application:

ARR, FACS, ICC, IP, WB

Citations:

$587.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

ABL-148, monoclonal

mol wt

antigen 145 kDa

species reactivity

monkey, rat, human, mouse, bovine

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 1:2,000 using human melanoma cell extract

isotype

IgG2a

UniProt accession no.

P00519

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ABL1(25)
mouse ... Abl1(11350)
rat ... Abl1(311860)

Description

General description

The c-Abl protein contains three high mobility group-like domains that bind to AT-rich DNA in a cooperative manner.

c-Abl is a non-receptor tyrosine kinase with both cytoplasmic and nuclear functions. The Abl oncogen has been implicated in several human leukemias including nearly all chronic myelocytic leukemias.

c-Abl is a proto-oncogene product that belongs to Tyr protein kinase family. It has a crucial role in different cellular processes like- differentiation, adhesion and regulates DNA damage-induced apoptosis.

Immunogen

recombinant c-Abl, SH2 domain.

Application

Monoclonal anti-c-Abl antibody can be used in western blotting (diluted 1:2000) using melanoma cell extract from human. It can also be used in microarray and flow cytometry. Monoclonal anti-c-Abl antibody can be used for studying the mechanism of signaling pathways involving c-Abl. It may also be used for immunoprecipitation and immunocytochemistry.

Biochem/physiol Actions

Cytoplasmic c-Abl regulates SH2/SH3 adaptor protein cytoskeleton-associated adaptor protein (Crk) and the Crk-binding protein p130cas. Nuclear c-Abl has been implicated in the regulation of cell cycle-dependent and DNA damage-induced gene expression.

Mouse anti-c-Abl antibody reacts specifically with an epitope present in the SH2 domain of the c-Abl. The product has also shown reactivity for c-Abl of monkey, rat, bovine, mouse and human.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA028409	HPA027251	SAB4300641
Sigma-Aldrich A5844 Monoclonal Anti-c-Abl antibody produced in mouse	Sigma-Aldrich HPA028409 Anti-ABL1 antibody produced in rabbit	Sigma-Aldrich HPA027251 Anti-ABL1 antibody produced in rabbit	Sigma-Aldrich SAB4300641 Anti-ABL1/2 (Ab-393/429) antibody produced in rabbit
description clone ABL-148, ascites fluid	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1	description affinity isolated antibody
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
clone ABL-148, monoclonal	clone polyclonal	clone polyclonal	clone polyclonal
species reactivity monkey, rat, human, mouse, bovine	species reactivity human	species reactivity human	species reactivity human, mouse
antibody form ascites fluid	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Gene Information human ... ABL1(25) mouse ... Abl1(11350) rat ... Abl1(311860)	Gene Information human ... ABL1(25)	Gene Information human ... ABL1(25)	Gene Information human ... ABL1(25), ABL2(27) mouse ... ABL1(11350), ABL2(11352)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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