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Anti-ARP3 antibody, Mouse monoclonal

Name: Anti-ARP3 antibody, Mouse monoclonal
Brand: SIGMA
Price: 189 USD
Availability: InStock

clone FMS338, purified from hybridoma cell culture

Synonym(s):

ARP3 Detection Antibody, Mouse Anti-ARP3

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Size/SKU	Availability	Price
25 μL	Available to ship TODAYfromMILWAUKEE	$189.00
100 μL	Available to ship TODAYfromMILWAUKEE	$575.00 $488.75
200 μL	Available to ship TODAYfromMILWAUKEE	$760.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD04118400

Conjugate:

unconjugated

Clone:

FMS338, monoclonal

Application:

ARR, ELISA (i), ICC, WB

Citations:

$189.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

FMS338, monoclonal

form

buffered aqueous solution

mol wt

antigen 40-45 kDa

species reactivity

human, mouse, rat, canine

packaging

antibody small pack of 25 μL

technique(s)

immunocytochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.25-0.5 μg/mL using total cell extract of mouse myoblast C2 cells

isotype

IgG2b

UniProt accession no.

P61158

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ACTR3(10096)
mouse ... Actr3(74117)
rat ... Actr3(81732)

Description

General description

Monoclonal Anti-ARP3 (mouse IgG2b isotype) is derived from the hybridoma FMS338 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with recombinant human ARP3. Arp3 is mapped to human chromosome 2q14.1.

Immunogen

recombinant human ARP3.

Application

Monoclonal Anti-ARP3 antibody produced in mouse has been used in:

enzyme linked immunosorbent assay (ELISA)
immunocytochemistry
immunoblotting
immunoprecipitation
immunofluorescence
immunohistochemistry

Biochem/physiol Actions

The ARP2/3 complex consists of seven distinct proteins (Arp2 and Arp3, p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc) that modulate polymerization of cellular actin filaments. ARP3 regulates actin nucleation, and is involved in directing the movement of Listeria monocytogenes in infected host cells. Monoclonal Anti-ARP3 antibody binds to human, canine, rat, and mouse ARP3.

The actin-related protein-2/3 (ARP2/3) is part of Wiskott-Aldrich Syndrome protein (WASP) signaling in mediating polymerization state of actin filaments. It has been found that ARP2/3 complex and its activator spinocerebellar ataxia, autosomal recessive 2 (Scar2) are involved in Golgi polarization in NIH 3T3 cells. However in primary astrocytes, Golgi polarization involves neither actin cytoskeleton or Arp2/3 complex nor any WASP-family of proteins. In a different model, it was found that the ARP2/3 complex was necessary for neutrophil chemotaxis and phagocytosis. By genetic and loss of function studies, it was demonstrated that Scar2 is the major regulator of the ARP2/3 complex rather than the WASP family of proteins, the latter having more restricted roles in specific cellular events.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200473	SAB4200366	C7104
Sigma-Aldrich A5979 Anti-ARP3 antibody, Mouse monoclonal	Sigma-Aldrich SAB4200473 Anti-EpCAM ICD antibody, Mouse monoclonal	Sigma-Aldrich SAB4200366 Anti-IKZF1/IKAROS antibody, Mouse monoclonal	Sigma-Aldrich C7104 Anti-Cdc27 antibody,Mouse monoclonal
description clone FMS338, purified from hybridoma cell culture	description clone 4A7, purified from hybridoma cell culture	description clone E1.14, purified from hybridoma cell culture	description clone AF3.1, purified from hybridoma cell culture
antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture
Gene Information human ... ACTR3(10096) mouse ... Actr3(74117) rat ... Actr3(81732)	Gene Information human ... EPCAM(4072) mouse ... Epcam(17075)	Gene Information human ... IKZF1(10320)	Gene Information human ... CDC27(996) mouse ... Cdc27(217232) rat ... Cdc27(360643)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity human, mouse, rat, canine	species reactivity human, mouse	species reactivity rat, monkey, human, mouse	species reactivity mouse, Xenopus, rat, bovine, canine, human
clone FMS338, monoclonal	clone 4A7, monoclonal	clone E1.14, monoclonal	clone AF3.1, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c