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A6469

Apelin-13 trifluoroacetate salt

≥95%, APJ receptor agonist, powder

Sinonimo/i:

Prepro-65-77-Apelin

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Taglio della confezioneSKUDisponibilitàPrezzo
1 mg
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CHF 317.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C69H111N23O16S · C2F3O2
Peso molecolare:
1663.84
UNSPSC Code:
12352202
PubChem Substance ID:
329770894
NACRES:
NA.32
Assay:
≥95%
Form:
powder
Quality level:
200

CHF 317.00

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

Apelin-13 trifluoroacetate salt, ≥95%

Quality Level

200

assay

≥95%

form

powder

UniProt accession no.

Q9ULZ1

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(O)=O

InChI

1S/C69H111N23O16S.C2HF3O2/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40;3-2(4,5)1(6)7/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79);(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-;/m0./s1

InChI key

IUOVYCLNUOUEHV-PDGAQFIRSA-N

Gene Information

human ... APLN(8862)

General description

Apelin is a regulatory peptide and a ligand of the APJ receptor. It is a member of the G protein-coupled receptor family. Apelin and APJ are broadly dispersed in the body.

Application

Apelin-13 trifluoroacetate salt has been used to determine whether apelin promotes progression of diabetic nephropathy (DN) by inducing podocyte dysfunction. It has also been used to examine the effects of apelin on myocardial infarction (MI) injury and underlying mechanisms.

Biochem/physiol Actions

Synthetic endogenous peptide agonist for the human APJ receptor, a putative receptor protein related to the angiotensin receptor (AT1). This peptide exerted an acidification-rate-promoting activity in CHO cells expressing the APJ receptor with a median effective concentration (EC50) value of 0.37 nM. Blocks HIV-1 and HIV-2 entry into cells expressing the APJ receptor.
Apelin plays physiological roles in the cytoprotection of many internal organs. It is used to treat insulin resistance and hypertension, but it may also can act as a negative factor. Apelin also regulates cardiovascular diseases.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Questo articolo
SML2083SML2084E3285
Apelin-13 trifluoroacetate salt ≥95%

Sigma-Aldrich

A6469

Apelin-13 trifluoroacetate salt

[Ala13]-Apelin-13 trifluoroacetate salt ≥96% (HPLC)

Sigma-Aldrich

SML2083

[Ala13]-Apelin-13 trifluoroacetate salt

[Pyr1]-Apelin-13 trifluoroacetate salt ≥96% (HPLC)

Sigma-Aldrich

SML2084

[Pyr1]-Apelin-13 trifluoroacetate salt

EIINFEKL trifluoroacetate salt ≥95% (HPLC)

Sigma-Aldrich

E3285

EIINFEKL trifluoroacetate salt

form

powder

form

powder

form

powder

form

powder

assay

≥95%

assay

≥96% (HPLC)

assay

≥96% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... APLN(8862)

Gene Information

-

Gene Information

-

Gene Information

-

UniProt accession no.

Q9ULZ1

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

-

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000422534
0000422534
0000219989
0000219989
0000164992

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M X Zou et al.
FEBS letters, 473(1), 15-18 (2000-05-10)
The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the
Jiming Yin et al.
Cell death & disease, 9(10), 1031-1031 (2018-10-12)
The epithelial-mesenchymal transition (EMT) of podocytes had been reported to be involved in the glomerular fibrosis in diabetic kidney diseases, which was regulated by TGFβ and NFκB pathways. And apelin, an adipokine which is upregulated in diabetic kidney diseases, was
Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities.
Guo C
Journal of Cellular and Molecular Medicine, 19(9), 2273-2285 (2015)
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Numero articolo commerciale globale

SKUGTIN
A6469-1MG04061826149331

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