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A7275

L-2-Aminoadipic acid

≥98% (TLC), powder, glutamine synthetase inhibitor

Synonym(s):

(S)-2-Aminohexanedioic acid, L-Homoglutamic acid, Aad

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Size/SKUAvailabilityPrice
100 mg

Estimated to ship TODAYfromMILWAUKEE

$57.00
250 mg

Estimated to ship TODAYfromMILWAUKEE

$105.00
1 g

Estimated to ship onSeptember 25, 2026fromMILWAUKEE

$314.00
5 g

Estimated to ship TODAYfromMILWAUKEE

$1,180.00

About This Item

Linear Formula:
HO2C(CH2)3CH(NH2)CO2H
CAS Number:
Molecular Weight:
161.16
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1724348
Assay:
≥98% (TLC)
Form:
powder

$57.00


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Product Name

L-2-Aminoadipic acid, ≥98% (TLC)

Quality Segment

assay

≥98% (TLC)

form

powder

mp

203-205 °C (dec.) (lit.)

SMILES string

N[C@@H](CCCC(O)=O)C(O)=O

InChI

1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1

InChI key

OYIFNHCXNCRBQI-BYPYZUCNSA-N

General description

L-2-Aminoadipic acid/α-aminoadipate is a gliotoxin and is a structural analog of glutamine. It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways.

Application

L-2-Aminoadipic acid has been used as a gliotoxin specific for astrocytes in rat. It has also been as an internal standard in the amino acid analysis from fermented food sample.

Biochem/physiol Actions

L-2-Aminoadipic acid inhibits glutamine synthetase and γ-glutamylcysteine synthetase. It modulates glucose metabolism and is present in higher levels in diabetic patients. L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes.

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form

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form

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Gene Information

human ... GLUL(2752), LGSN(51557)
rat ... Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Grm6(24419)

Gene Information

rat ... Grin2a(24409), Grm1(24414), Grm2(24415), Grm6(24419)

Gene Information

-

Gene Information

-

mp

203-205 °C (dec.) (lit.)

mp

208-210 °C (lit.)

mp

203-205 °C

mp

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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