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A7606

Aprindine hydrochloride

≥98% (HPLC), solid

Synonym(s):

N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride, Amidonal

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Size/SKUAvailabilityPrice
10 mg
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$213.00
50 mg
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$840.00

About This Item

Empirical Formula (Hill Notation):
C22H30N2 · HCl
CAS Number:
33237-74-0
Molecular Weight:
358.95
NACRES:
NA.77
PubChem Substance ID:
329770937
UNSPSC Code:
12352200
EC Number:
251-418-7
MDL number:
MFCD01698392
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated

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Quality Segment

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3

InChI

1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H

InChI key

KIPFVRHNAAZJOD-UHFFFAOYSA-N

Application

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.

Biochem/physiol Actions

Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker.
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
C6617P3495
Aprindine hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

A7606

Aprindine hydrochloride

CBIQ ≥98% (HPLC), solid

Sigma-Aldrich

C6617

CBIQ

Phrixotoxin-2 >98% (HPLC), lyophilized powder

Sigma-Aldrich

P3495

Phrixotoxin-2

description

≥98% (HPLC), solid

description

≥98% (HPLC), solid

description

>98% (HPLC), lyophilized powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

form

solid

form

solid

form

lyophilized powder

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage condition

desiccated

storage condition

-

storage condition

-

solubility

H2O: >10 mg/mL

solubility

DMSO: 15 mg/mL

solubility

-

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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