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Anti-Beta (β)-Amyloid antibody

Name: Anti-Beta (β)-Amyloid antibody
Brand: SIGMA
Price: 989 USD
Availability: InStock

rabbit polyclonal

Enhanced Validation

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Size/SKU	Availability	Price
0.5 mL	Available to ship TODAYfromMILWAUKEE	$989.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00212892

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IHC (p)

Citations:

$989.00

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Properties

Product Name

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit, whole antiserum

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

15 mM sodium azide

species reactivity

human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using human Alzheimer’s disease (AD) brain tissue, indirect ELISA: 1:4000-1:8000

UniProt accession no.

P05067

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)

Description

General description

Amyloid precursor proteins (APPs) are members of a large family of 70 kDa transmembrane glycoproteins that are found in a wide range of tissues. APP is expressed in the brain. It is located on human chromosome 21. APPs have three main isoforms, namely, APP₆₉₅, APP₇₅₁ and APP₇₇₀, that are derived from alternative splicing events in cells.

Immunogen

synthetic β-amyloid (1-40) conjugated to BSA.

Application

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit has been used in:

immunocytochemical localization of Aβ peptides
immunocytochemistry
immunoprecipitation
focused ultrasound-microbubble enhanced antibody delivery (FUS-MB)

Biochem/physiol Actions

The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).
Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.

Physical form

Rabbit Anti-β-Amyloid (1-40) is supplied as a liquid containing 0.1% sodium azide as preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	A8978	A3356	A8354
Sigma-Aldrich A8326 Anti-β-Amyloid Protein (1-40) antibody produced in rabbit	Sigma-Aldrich A8978 Anti-β-Amyloid (13-28) antibody, Mouse monoclonal	Sigma-Aldrich A3356 Anti-β-Amyloid (22-35) antibody produced in rabbit	Sigma-Aldrich A8354 Anti-β-Amyloid antibody, Mouse monoclonal
description whole antiserum	description clone BAM90.1, purified from hybridoma cell culture	description affinity isolated antibody, buffered aqueous solution	description clone NAB 228, purified from hybridoma cell culture
biological source rabbit	biological source mouse	biological source rabbit	biological source mouse
antibody form whole antiserum	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
clone polyclonal	clone BAM90.1, monoclonal	clone polyclonal	clone NAB 228, monoclonal
UniProt accession no. P05067	UniProt accession no. P05067	UniProt accession no. P05067	UniProt accession no. P05067

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

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