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Anti-Beta (β)-Amyloid antibody

Name: Anti-Beta (β)-Amyloid antibody
Brand: SIGMA
Price: 955 USD
Availability: InStock

Enhanced Validation

rabbit polyclonal

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Size/SKU	Availability	Price
0.5 mL	Available to ship TODAYfromMILWAUKEE	$955.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00212892

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IHC (p)

Citations:

$955.00

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Properties

Product Name

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit, whole antiserum

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

15 mM sodium azide

species reactivity

human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using human Alzheimer’s disease (AD) brain tissue, indirect ELISA: 1:4000-1:8000

UniProt accession no.

P05067

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)

Description

General description

Amyloid precursor proteins (APPs) are members of a large family of 70 kDa transmembrane glycoproteins that are found in a wide range of tissues. APP is expressed in the brain. It is located on human chromosome 21. APPs have three main isoforms, namely, APP₆₉₅, APP₇₅₁ and APP₇₇₀, that are derived from alternative splicing events in cells.

Immunogen

synthetic β-amyloid (1-40) conjugated to BSA.

Application

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit has been used in:

immunocytochemical localization of Aβ peptides
immunocytochemistry
immunoprecipitation
focused ultrasound-microbubble enhanced antibody delivery (FUS-MB)

Biochem/physiol Actions

The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).
Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.

Physical form

Rabbit Anti-β-Amyloid (1-40) is supplied as a liquid containing 0.1% sodium azide as preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	A8717	A3981	A5213
Sigma-Aldrich A8326 Anti-β-Amyloid Protein (1-40) antibody produced in rabbit	$Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich A8717 Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit	Sigma-Aldrich A3981 Anti-β-Amyloid antibody, Mouse monoclonal	Sigma-Aldrich A5213 Anti-β-Amyloid antibody, Mouse monoclonal
description whole antiserum	description IgG fraction of antiserum, buffered aqueous solution	description clone BAM-10, purified from hybridoma cell culture	description clone BAM-10, ascites fluid
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
antibody form whole antiserum	antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form ascites fluid
biological source rabbit	biological source rabbit	biological source mouse	biological source mouse
species reactivity human	species reactivity mouse, human, rat	species reactivity human	species reactivity human
Gene Information human ... APP(351)	Gene Information human ... APP(351) mouse ... App(11820) rat ... App(54226)	Gene Information human ... APP(351)	Gene Information human ... APP(351)

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c