Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

A8967

Anti-Amyloid Precursor Protein (APP) Antibody

Name: Anti-Amyloid Precursor Protein (APP) Antibody
Brand: SIGMA
Price: 498.1 EUR
Availability: InStock

rabbit polyclonal

Synonym(e):

Anti-APP

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Ansicht ändern

Ihnen/SKU	Verfügbarkeit	Preis
0.2 mL	Ab HEUTE lieferbarvonSchnelldorf	586,00 € 498,10 €

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02095830

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (p), WB

Citations:

498,10 €

Listenpreis586,00 €Sparen Sie 15%

Aktion nur im Web

Ab HEUTE lieferbarDetails

Für Ihr Target ist ein rekombinanter, konservierungsmittelfreier Antikörper verfügbar. Probieren Sie ZMS1012

Sonderanfertigung anfragen

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Eigenschaften

Produktname

Anti-Amyloid Precursor Protein, N-Terminal antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 95-100 kDa

species reactivity

human, rat, mouse

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formic acid-treated sections of human Alzheimer′s disease (AD) brain, microarray: suitable, western blot: 1:1,000 using rat brain extract or supernatant of 293T cells secreting APP.

UniProt accession no.

P05067

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)
mouse ... App(11820)
rat ... App(54226)

Beschreibung

General description

Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. It is expressed at high levels in the brain. APP gene is mapped to human chromosome 21q11.2-q21. It is a 695 amino acid protein which possesses a large ectodomain and comparatively short intracellular region.

The immunogen sequence is identical to the APP isoforms APP₇₅₁ and APP₇₇₀ and is highly conserved (single amino acid substitution) in rat and mouse APP₆₉₅. The antibody recognizes APP₆₉₅, APP₇₅₁ and APP₇₇₀.

Immunogen

synthetic peptide corresponding to the N-terminal of human APP₆₉₅ (amino acids 46-60) conjugated to KLH.

Application

Anti-Amyloid Precursor Protein, N-Terminal antibody produced in rabbit has been used in:

western blotting
immunostaining
immunofluorescence

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

SH-SY5Y cell lysates were analyzed by western blot using rabbit anti-Amyloid Precursor Protein, C-Terminal as the primary antibody at a 1:500 dilution.

Biochem/physiol Actions

Amyloid precursor proteins (APPs) regulates cell growth, motility, neurite outgrowth and cell survival. The intracellular C-terminus of APP serves as a transcriptional regulator and as a receptor for kinesin-1-mediated axonal transport. Alzheimer′s disease is characterized by deposition of amyloid in the central nervous system, in neurite plaques and on cerebral vasculature. Mutations in the APP gene are linked with rare forms of autosomal dominant familial Alzheimer′s Disease (FAD). APPs undergo post-translational processing including N- and O-glycosylation, phosphorylation and sulfation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 1

Dieser Artikel	A8717	A8326	A1976
$Anti-Amyloid Precursor Protein, N-Terminal antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich A8967 Anti-Amyloid Precursor Protein, N-Terminal antibody produced in rabbit	$Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich A8717 Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit	Sigma-Aldrich A8326 Anti-β-Amyloid Protein (1-40) antibody produced in rabbit	Sigma-Aldrich A1976 Anti-Amyloid Peptide β, Cleavage Site 42 antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form whole antiserum	antibody form affinity isolated antibody
form buffered aqueous solution	form buffered aqueous solution	form liquid	form buffered aqueous solution
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal

Still not finding the right product?

Explore all of our products under Anti-Amyloid Precursor Protein, N-Terminal antibody produced in rabbit

— oder —

Probieren Sie unser Produkt-Auswahlhilfe, um Ihre Auswahl einzugrenzen

Lagerklasse

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c