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A9227

ABT-491 hydrochloride

≥98% (HPLC), active platelet-activating factor (PAF) receptor antagonist, solid

Synonym(s):

4-Ethynyl-N,N-dimethyl-3-[3-fluoro-4-[(2-methyl-1H-imidazo-[4,5-c]pyridin-1-yl)methyl]benzoyl]-1H-indole-1-carboxamide hydrochloride, A-137491

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Size/SKUAvailabilityPrice
5 mg
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$293.00
25 mg
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$1,090.00

About This Item

Empirical Formula (Hill Notation):
C28H22N5O2F · HCl
CAS Number:
Molecular Weight:
515.97
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated

$293.00


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Product Name

ABT-491 hydrochloride, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

mp

170-178 °C (lit.)

solubility

H2O: freely soluble 22 mg/mL

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c5c(cccc15)C#C

InChI

1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H

InChI key

AWRGBOKANQBIBM-UHFFFAOYSA-N

Biochem/physiol Actions

Highly potent, selective and orally active platelet-activating factor (PAF) receptor antagonist. Ki = 0.6 nM in human platelets.

Features and Benefits

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
511071A5111SML2660
description

≥98% (HPLC)

description

The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications.

description

≥98% (HPLC)

description

≥98% (HPLC)

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated (hygroscopic), OK to freeze, protect from light

storage condition

desiccated

storage condition

desiccated

solubility

H2O: freely soluble 22 mg/mL

solubility

water: 10 mg/mL

solubility

H2O: >30 mg/mL

solubility

DMSO: 2 mg/mL, clear


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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