The A9477 is the d-Aldosterone (per our supplier), which is considered to be the biologically active isomer.
A9477
Aldosterone
≥95% (HPLC), powder
Synonym(s):
11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Available to ship TODAYfromMILWAUKEE | $119.00 | |
| 25 mg | Available to ship TODAYfromMILWAUKEE | $414.00 | |
| 100 mg | Available to ship TODAYfromMILWAUKEE | $1,210.00 |
About This Item
Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
Molecular Weight:
360.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-139-9
MDL number:
Beilstein/REAXYS Number:
3224996
$119.00
Available to ship TODAYDetails
Subscriptions are currently unavailable.
Ships Every 4 weeks
Product Name
Aldosterone, ≥95% (HPLC)
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥95% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow
shipped in
ambient
storage temp.
room temp
SMILES string
C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O
InChI
1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
InChI key
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Gene Information
human ... SERPINA6(866)
rat ... Ar(24208), Nr3c2(25672)
General description
Aldosterone plays a significant role in the multi-factorial regulation of salt, potassium, blood pressure, and acid-base balance. It is also involved in maternal volume expansion during fetal development to support fetal perfusion and may contribute to the increased expression of placental growth factors. While its primary activity is associated with the kidney, aldosterone can also interact with mineralocorticoid receptors in other tissues such as the gastrointestinal tract, respiratory epithelium, myocardium, and vascular smooth muscle. Aldosterone antagonists or mineralocorticoid receptor antagonists (MRAs) can be beneficial for patients with various clinical conditions, including primary aldosteronism (PA), primary and resistant hypertension, heart failure (HF), and chronic kidney disease (CKD).
Application
Aldosterone has been used:
- as a RPMI-1640 medium supplement for podocyte culture to test its pathogenicity in obesity-related glomerulopathy (ORG)
- in combination with salt to induce renal injury in mice
- to stimulate primary liver sinusoidal endothelial cells (LSECs) and in the generation of hyperaldosteronism model in mice
The d-isomer of aldosterone is considered to be the biologically active isomer.
Biochem/physiol Actions
Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex. It induces urinary excretion of K+ and renal reabsorption of Na+. It is produced from adrenocorticotropic hormone (ACTH) and is essential for maintaining sodium homeostasis in the distal tubules. Aldosterone binds to the mineralocorticoid receptor and may modulate vascular system and induce kidney damage. It contributes to the progression of chronic kidney disease(CKD). Aldosterone is part of the renin-angiotensin-aldosterone system (RAAS).
Other Notes
Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥95% (HPLC) | assay ≥92% | assay ≥95% | assay ≥99% (HPLC) |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) inhibition assay: suitable | technique(s) cell culture | mammalian: suitable |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| solubility chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow | solubility chloroform: 50 mg/mL, clear, colorless to faintly yellow | solubility chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow | solubility chloroform: methanol (1:1): 20 mg/mL, clear to slightly hazy, colorless to light yellow |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Aldosterone and renin measurements
Cartledge S and Lawson N
Annals of Clinical Biochemistry, 37(3), 262-278 (2000)
Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone-and salt-induced renal injury
Hisamichi M
Hypertension Research, 41(1), 8-8 (2018)
Physiology, Aldosterone
Scott, JH, et al.
StatPearls [Internet] (2023)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A9477-100MG | 04061833402580 |
| A9477-25MG | 04061833402597 |
| A9477-5MG | 04061833402641 |
-
Is Product A9477, Aldosterone, the d- or l- isomer?
1 answer-
Helpful?
-
-
Is Product A9477, Aldosterone, tested for solubility?
1 answer-
Yes, A9477 is tested for solubility using 20mg/ml in chloroform. For biological applications, you can solubilize aldosterone in ethanol to at least 1 mg/mL. Please refer to literature references for further solubility information.
Helpful?
-
-
What is the difference between Aldosterone Products A9477 and 05521?
1 answer-
The main differences between A9477 and 05521 are the assays performed on the products. The assay results are lot specific and can be viewed on the Certificate of Analysis.
Helpful?
-
-
How do I make a stock solution of Product A9477, Aldosterone?
1 answer-
To prepare a 100 μg/ml stock solution, add 5 ml of absolute ethanol to 5 mg, gently swirl to dissolve, then add 45 ml sterile medium. Freeze the stock in working aliquots, but avoid repeated freeze/thaw cycles.
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-