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A9789

Anisomycin

from Streptomyces griseolus, ≥98% (HPLC), solid, protein synthesis inhibitor

Synonym(s):

(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin

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5 mg

Available to ship TODAYfromMilliporeSigma Canada Ltd.

$81.40
25 mg

Available to ship TODAYfromMilliporeSigma Canada Ltd.

$273.00
100 mg
Please contact Customer Service for Availability
$834.00

About This Item

Empirical Formula (Hill Notation):
C14H19NO4
CAS Number:
22862-76-6
Molecular Weight:
265.30
NACRES:
NA.77
PubChem Substance ID:
24891496
UNSPSC Code:
12352200
EC Number:
245-269-7
MDL number:
MFCD00077650
Beilstein/REAXYS Number:
20705
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
300

$81.40

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Product Name

Anisomycin from Streptomyces griseolus, ≥98% (HPLC), solid

Quality Level

300

assay

≥98% (HPLC)

form

solid

color

white to faint yellow

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), DMSO: 20 mg/mL, methanol: 20 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1

InChI

1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1

InChI key

YKJYKKNCCRKFSL-RDBSUJKOSA-N

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

Disclaimer

Hygroscopic

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This Item
A5862S7809SML0918
Anisomycin from Streptomyces griseolus ≥98% (HPLC), solid

Sigma-Aldrich

A9789

Anisomycin from Streptomyces griseolus

Anisomycin Ready Made Solution from Streptomyces griseolus, 10 mg/mL in DMSO

Sigma-Aldrich

A5862

Anisomycin

SKF-96365 ≥98% (HPLC), solid

Sigma-Aldrich

S7809

SKF-96365

CID44216842 ≥98% (HPLC)

Sigma-Aldrich

SML0918

CID44216842

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

liquid, ready-to-use solution

form

solid

form

powder

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), methanol: 20 mg/mL, DMSO: 20 mg/mL

solubility

-

solubility

DMSO: >20 mg/mL, H2O: >20 mg/mL

solubility

DMSO: 20 mg/mL, clear

color

white to faint yellow

color

-

color

white

color

white to beige

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000510740
0000510740
0000453631
0000453631
0000442830

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Global Trade Item Number

SKUGTIN
A9789-25MG04061833412459
A9789-100MG04061833412442
A9789-5MG04061833412466

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