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A9789

Anisomycin

from Streptomyces griseolus, ≥98% (HPLC), solid, protein synthesis inhibitor

Synonym(s):

(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$62.00
25 mg

Available to ship TODAYfromMILWAUKEE

$210.00
100 mg

Available to ship TODAYfromMILWAUKEE

$628.00

About This Item

Empirical Formula (Hill Notation):
C14H19NO4
CAS Number:
Molecular Weight:
265.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-269-7
MDL number:
Beilstein/REAXYS Number:
20705
Assay:
≥98% (HPLC)
Form:
solid

$62.00


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Product Name

Anisomycin from Streptomyces griseolus, ≥98% (HPLC), solid

Quality Segment

assay

≥98% (HPLC)

form

solid

color

white to faint yellow

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), DMSO: 20 mg/mL, methanol: 20 mg/mL

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1

InChI

1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1

InChI key

YKJYKKNCCRKFSL-RDBSUJKOSA-N

Biochem/physiol Actions

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

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Hygroscopic

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This Item
A5862S7809D6942
description

≥98% (HPLC), solid

description

Ready Made Solution from Streptomyces griseolus, 10 mg/mL in DMSO

description

≥98% (HPLC), solid

description

≥98% (HPLC), solid

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

liquid, ready-to-use solution

form

solid

form

solid

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), methanol: 20 mg/mL, DMSO: 20 mg/mL

solubility

-

solubility

DMSO: >20 mg/mL, H2O: >20 mg/mL

solubility

H2O: ~20 mg/mL

color

white to faint yellow

color

-

color

white

color

white


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pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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