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N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin

Name: N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

Ac-YVAD-AFC

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About This Item

Linear Formula:

C₃₃H₃₆N₅O₁₀F₃

Molecular Weight:

719.66

NACRES:

NA.32

PubChem Substance ID:

329771064

UNSPSC Code:

12352209

MDL number:

MFCD01318881

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Properties

Quality Segment

200

assay

≥95% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI

1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1

InChI key

GWKJISJKNKIJNP-DEQDFGQZSA-N

Gene Information

human ... CASP1(834), CASP4(837)
mouse ... CASP1(12362), CASP4(12363)
rat ... CASP1(25166), CASP4(114555)

Description

General description

Membrane-permeable fluorogenic substrate for caspase 1 (ICE) and caspase 4 (TX).

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This Item	A0466	C6608	A6220
Sigma-Aldrich A9965 N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin	Sigma-Aldrich A0466 N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin	Sigma-Aldrich C6608 N-Acetyl-Lys-Pro-Arg-7-amido-4-trifluoromethylcoumarin	Sigma-Aldrich A6220 N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin
assay ≥95% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form solid	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color white	color white	color -	color -
Gene Information human ... CASP1(834), CASP4(837) mouse ... CASP1(12362), CASP4(12363) rat ... CASP1(25166), CASP4(114555)	Gene Information human ... CASP3(836)	Gene Information -	Gene Information human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002) mouse ... CFLAR(117279), GZMB(171528) rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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