ABK0020
SHP2Bridge ELISA
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| Size/SKU | Availability | Price |
|---|---|---|
1 kit | Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery) | $1,520.00 |
About This Item
NACRES:
NA.84
UNSPSC Code:
41116158
Species reactivity:
mouse, human
Storage temp.:
2-8°C
Shipped in:
wet ice
$1,520.00
Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
antibody form
purified antibody
Quality Segment
species reactivity
mouse, human
technique(s)
ELISA: suitable
shipped in
wet ice
storage temp.
2-8°C
General description
A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is pre-coated with a panel of 27 antibodies raised against peptides derived from the full length protein sequence of SHP2, a total of 27 columns will be used, each column is pre-coated with one specific antibody covering one region of SHP2 (about 30 amino acids in length). Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of some of them is masked by the three dimensional structure (Higher Order Structure, or HOS) of the protein and only a certain number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for correctly folded SHP2. For a testing sample from cancer tissue, cell line or purified SHP2, if the protein is not mutated or the mutations do not impact the SHP2 HOS, the ‘fingerprint′ will match that of wild type SHP2. If the SHP2 mutations or a screened small molecule drug candidate resulted in the alteration of the protein HOS, changes in the ‘fingerprint′ generated by the ELISA will point out differences quantitively, this information may be valuable in the characterization of the SHP2 from cancer patient samples, cancer cell lines, other biological samples or the identification of small molecules that are SHP2 HOS disruptors (allosteric regulators).
Application
For research use only. Not for use in diagnostic procedures.
Other Notes
ELISA kit contains three 96-well microplates and all the components necessary to complete an ELISA test.
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This Item | |||
|---|---|---|---|
| description - | description - | description - | description - |
| species reactivity mouse, human | species reactivity human, mouse | species reactivity mouse, human | species reactivity mouse, human |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| technique(s) ELISA: suitable | technique(s) ELISA: suitable | technique(s) ELISA: suitable | technique(s) ELISA: suitable |
| shipped in wet ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| antibody form purified antibody | antibody form purified antibody | antibody form purified antibody | antibody form purified antibody |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
Storage Class
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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