AL11430
DMT-locA(bz) Phosphoramidite
configured for ABI
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Check Cart for Availability | $183.00 |
About This Item
biological source
non-animal source (BSE/TSE no Risk)
Quality Segment
product line
Proligo Reagents
assay
≥98.0% (31P-NMR), ≥98.0% (reversed phase HPLC)
form
powder
impurities
≤3 wt. % Residual Solvent Content, <0.4% Water Content (Karl Fischer), <0.5% Single unspecified Impurity (reversed phase HPLC)
color
white to off-white
solubility
soluble, clear, colorless
absorption
<0.1 in acetonitrile at 0.2 M
suitability
conforms to structure for H-NMR, conforms to structure for LC-MS
compatibility
configured for ABI
storage temp.
−20°C
General description
With the exception of the LNA monomers, LNA synthesis is accomplished with the same reagents as DNA synthesis. LNA phosphoramidites from Merck are diluted with dry acetonitrile, except for locMeC(bz)-phosphoramidite. This phosphoramidite requires the application of a cosolvent to prevent crystallization from the solution on the synthesizer. Dichloromethane or tetrahydrofuran (THF) can be applied as co-solvents with acetonitrile to completely dissolve locMeC(bz)-phosphoramidite.
Features and Benefits
- LNA oligonucleotides are prepared by phosphoramidite chemistry
- Standard DNA synthesizer platforms can be employed. No change is required in the reagents commonly used for DNA synthesis
- To further enhance the hybridization characteristics of LNA, 5-methyl-cytidine is employed instead of cytidine
- LNA monomers are as soluble in acetonitrile as their DNA counterparts (except for the 5-methyl-cytidine derivative, which requires the application of 10-20%, dichloromethane as a co-solvent)
- Mixmer oligonucleotides containing LNA, DNA and/or RNA monomers can be assembled easily
- LNA oligonucleotides with predefined melting temperatures (Tm) can be designed and prepared
Other Notes
Legal Information
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This Item | |||
|---|---|---|---|
| description configured for ABI | description - | description configured for PerkinElmer | description configured for ABI |
| biological source non-animal source (BSE/TSE no Risk) | biological source non-animal source (BSE/TSE no Risk) | biological source non-animal source (BSE/TSE no Risk) | biological source non-animal source (BSE/TSE no Risk) |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 300 |
| assay ≥98.0% (31P-NMR), ≥98.0% (reversed phase HPLC) | assay ≥98.0% (reversed phase HPLC), ≥98.0% (31P-NMR) | assay ≥98.0% (reversed phase HPLC), ≥98.0% (31P-NMR) | assay ≥98.0% (reversed phase HPLC), ≥98.0% (31P-NMR) |
| form powder | form powder | form powder | form powder |
| solubility soluble, clear, colorless | solubility soluble, clear, colorless | solubility soluble, clear, colorless | solubility acetonitrile: 0.2 M, clear, colorless |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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