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B0560

(−)-Blebbistatin

≥98% (HPLC), solid, cell cycle inhibitor

Synonyme(s) :

1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one

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1 mg

Disponible dès aujourd'huiDeSt QuentinFallavier

152,00 €
5 mg

Disponible dès aujourd'huiDeSt QuentinFallavier

551,00 €

A propos de cet article

Formule empirique (notation de Hill) :
C18H16N2O2
Numéro CAS:
856925-71-8
Poids moléculaire :
292.33
UNSPSC Code:
12352200
PubChem Substance ID:
329773119
NACRES:
NA.77
MDL number:
MFCD08460907
Form:
solid

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Nom du produit

(−)-Blebbistatin, solid, synthetic

Quality Segment

200

form

solid

solubility

DMSO: 5 mg/mL, chloroform: soluble(lit.), ethyl acetate: soluble(lit.), methanol: soluble(lit.), methylene chloride: soluble(lit.)

storage temp.

−20°C

SMILES string

Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c4ccccc4

InChI

1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1

InChI key

LZAXPYOBKSJSEX-GOSISDBHSA-N

General description

(-)-Blebbistatin, a bioactive small molecule, is a selective inhibitor of skeletal muscle and non-muscle myosin II isoforms.[1]The mechanism of action of blebbistatin, a myosin II ATPase inhibitor, does not influence other members of the myosin superfamily, such as I, V, and X.Blebbistatin is highly light sensitive, and photobleaching can reverse its effect completely. Blebbistatin is a commonly used as excitation-contraction uncoupling agent in cardiovascular physiology. Blebbistatin controls the inhibitory effect of thrombin on intercellular Ca2+ wave propagation. Blebbistatin reduces cardiac contractility by stabilizing the OFF state of the thick filament.Blebbistatin’s selectivity and affinity for multiple class II myoisin make it an attractive candidate for use in cell motility research and muscle physiology.[1]

Application

(−)-Blebbistatin has been used to investigate the effect on cardiac contractility and effect of thrombin on actomyosin contractility

Biochem/physiol Actions

(-)-Blebbistatin is a cell cycle inhibitor; selective inhibitor of non-muscle myosin II.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Cet article
203390203391203895
(−)-Blebbistatin solid, synthetic

Sigma-Aldrich

B0560

(−)-Blebbistatin

(±)-Blebbistatin (±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells.

Sigma-Aldrich

203390

(±)-Blebbistatin

(-)-Blebbistatin The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.

Sigma-Aldrich

203391

(-)-Blebbistatin

BTS A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility.

Sigma-Aldrich

203895

BTS

description

solid, synthetic

description

(±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells.

description

The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.

description

A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility.

form

solid

form

solid

form

solid

form

crystalline solid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, ethyl acetate: soluble(lit.), methylene chloride: soluble(lit.), chloroform: soluble(lit.), methanol: soluble(lit.)

solubility

methanol: 1.5 mg/mL, 100% DMSO: 100 mg/mL, 90% DMSO: 75 mg/mL

solubility

methanol: 1.5 mg/mL, 100% DMSO: 100 mg/mL, 90% DMSO: 75 mg/mL

solubility

DMSO: 200 mg/mL

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