This product is not assigned an expiration date. When stored appropriately at ?20°C, the material is quite stable. A warranty period of 1 year from the date of shipment applies to this item. Usage beyond that period would be up to the end user.
B2515
L-Buthionine-sulfoximine
synthetic (organic), ≥97% (TLC), γ-glutamylcysteine synthetase inhibitor, powder
Synonym(s):
L-BSO
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| Size/SKU | Availability | Price |
|---|---|---|
500 mg | Check Cart for Availability | $311.00 |
1 g | Check Cart for Availability | $489.00 |
5 g | Check Cart for Availability | $1,710.00 |
About This Item
Empirical Formula (Hill Notation):
C8H18N2O3S
CAS Number:
Molecular Weight:
222.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
2367136
Product Name
L-Buthionine-sulfoximine, ≥97% (TLC)
biological source
synthetic (organic)
Quality Segment
assay
≥97% (TLC)
form
powder
mp
224-226 °C
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
SMILES string
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChI key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
Gene Information
human ... GCLC(2729), GCLM(2730)
Application
L-Buthionine-sulfoximine has been used:
- as a selective activator for the induction of ferroptosis in rat apoptotic cells
- as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
- as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages
Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
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This Item | |||
|---|---|---|---|
| description ≥97% (TLC) | description - | description ≥99% (GC) | description ≥98% (HPLC), powder |
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) |
| assay ≥97% (TLC) | assay ≥98% (TLC) | assay ≥99% (GC) | assay ≥98% (HPLC) |
| Gene Information human ... GCLC(2729), GCLM(2730) | Gene Information - | Gene Information - | Gene Information mouse ... Cnr2(12802) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| solubility water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility water: 50 mg/mL, clear to very slightly hazy, colorless to yellow | solubility water: 50 mg/mL, clear, colorless to faintly yellow | solubility 4 M NH4OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hi, I've kept this product (powder) in the fridge for a longer period (Approx. 1 year). Is it still okey to use or should I consider buying another one and keep it in the freezer?
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