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B3056

Bisindolylmaleimide II

≥97% (Mixture of 2 isomers)

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Pack SizeSKUAvailabilityPrice
1 mg
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$190.00

About This Item

Empirical Formula (Hill Notation):
C27H26N4O2
CAS Number:
137592-45-1
Molecular Weight:
438.52
NACRES:
NA.77
PubChem Substance ID:
329773212
UNSPSC Code:
12352111
MDL number:
MFCD00236430
Assay:
≥97% (Mixture of 2 isomers)
Form:
powder
Quality level:
200

$190.00

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biological source

synthetic (organic)

Quality Level

200

assay

≥97% (Mixture of 2 isomers)

form

powder

solubility

DMSO: soluble, ethanol: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26

InChI

1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)

InChI key

LBFDERUQORUFIN-UHFFFAOYSA-N

Application

Bisindolylmaleimide II (BIS II) has been used:
  • as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes[1]
  • as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity[2]
  • as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells[3]

Biochem/physiol Actions

Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.[3]

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This Item
B3306D5794SML1566
Bisindolylmaleimide II ≥97% (Mixture of 2 isomers)

Sigma-Aldrich

B3056

Bisindolylmaleimide II

Bisindolylmaleimide IV ≥98% (TLC), solid

Sigma-Aldrich

B3306

Bisindolylmaleimide IV

Diacylglycerol Kinase Inhibitor II solid

Sigma-Aldrich

D5794

Diacylglycerol Kinase Inhibitor II

Leucinostatin A+B mixture ≥95% (mixture of Leucinostatin A+B, HPLC), (Paecilomyces lilacinus)

Sigma-Aldrich

SML1566

Leucinostatin A+B mixture

assay

≥97% (Mixture of 2 isomers)

assay

≥98% (TLC)

assay

≥97% (HPLC)

assay

≥95% (mixture of Leucinostatin A+B, HPLC)

form

powder

form

solid

form

solid

form

powder

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: soluble, ethanol: soluble

solubility

DMSO: soluble, methanol: soluble

solubility

0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H2O: insoluble, ethanol: soluble, ethyl acetate: soluble

solubility

DMF: 10 mg/mL, DMSO: 10 mg/mL, ethanol: 10 mg/mL, methanol: 10 mg/mL

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

(Paecilomyces lilacinus)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN2224
SLCD5000
SLCC7849
SLBW7431
SLBP3894V

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S E Wang et al.
Oncogene, 29(23), 3335-3348 (2010-04-13)
Activating mutations in the tyrosine kinase domain of HER2 (ErbB2) have been identified in human cancers. Compared with wild-type HER2, mutant HER2 shows constitutively activate kinase activity and increased oncogenicity. Cells transformed by mutant HER2 are resistant to epidermal growth
Xiaojie Shi et al.
Brain research bulletin, 130, 138-145 (2017-01-25)
Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS)
Ameneh Cheshmehkani et al.
Biochemical pharmacology, 146, 139-150 (2017-09-26)
Agonism of the G protein-coupled free-fatty acid receptor-4 (FFA4) has been shown to promote numerous anti-inflammatory effects in macrophages that arise due to interaction with β-arrestin partner proteins. Humans express functionally distinct short and long FFA4 splice variants, such that
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Global Trade Item Number

SKUGTIN
B3056-1MG04061826121542

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