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B3170

Monoclonal Anti-Bcl-2 antibody produced in mouse

Name: Monoclonal Anti-Bcl-2 antibody produced in mouse
Brand: SIGMA
Price: 944762 KRW

clone Bcl-2-100, ascites fluid

동의어(들):

Anti-BCL-2

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팩 크기/SKU	재고 정보	가격 (VAT 별도)
0.2 mL	구입 가능 여부는 고객센터에 문의하십시오.	₩944,762

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00239644

Conjugate:

unconjugated

Clone:

Bcl-2-100, monoclonal

Application:

ARR, EM, ICC, IHC (f), IHC (p), IP, WB

Citations:

₩944,762

구입 가능 여부는 고객센터에 문의하십시오.

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도움 문의

속성

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

Bcl-2-100, monoclonal

mol wt

antigen 26 kDa

contains

15 mM sodium azide

species reactivity

human

should not react with

mouse

technique(s)

electron microscopy: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 1:1,000 using human HeLa cell extract

isotype

IgG1

UniProt accession no.

P10415

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2(596)

설명

General description

BCL2 (B-cell lymphoma 2) consists of pro- and antiapoptotic functions. It belongs to BCL2 family of proteins. It is mapped to human chromosome 18q21.3.

Immunogen

synthetic peptide corresponding to residues 41-54 of the Bcl-2 protein, conjugated to thyroglobulin.

Application

Anti-BCL2 (Ab-56) antibody has been used in western blotting and immunocytochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Monoclonal Anti-Bcl-2 antibody produced in mouse is suitable for western blotting at a concentration of 1:1,000 by using human HeLa cell extract. It is also suitable for immunohistochemistry by using formalin-fixed, paraffin-embedded tissue sections or frozen sections. Further, the antibody may be used for the localization of Bcl-2, by implementing numerous assays like- microarray, electron microscopy and immunoprecipitation.

Biochem/physiol Actions

BCL2 (B-cell lymphoma 2) plays an important role in the growth and progression of cancer. Overexpression of BCL2 (B-cell lymphoma 2) results in poor clinical predictions in diffuse large B-cell lymphoma (DLBCL). Bcl2 is highly essential for the survival of kidney and melanocyte stem cells and mature lymphocytes. It may control Bcl2 multiple initiator caspases.

Protooncogene BCL2 encodes a 26 kD integral outer mitochondrial membrane protein expressed in sub-cellular components such as the mitochondria and nucleus. While mitochondrial BCL2 inhibits apoptosis, BCL2 present in the nucleus may activate cell death. It may also regulate autophagy during starvation. Additionally, BCL2 facilitates the survival of central and peripheral neurons grown in culture in the absence of neurotrophic factors.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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차이점 표시

1 of 1

이 품목	SAB4500005	SAB4500003	SAB4300339
Sigma-Aldrich B3170 Monoclonal Anti-Bcl-2 antibody produced in mouse	Sigma-Aldrich SAB4500005 Anti-BCL-2 antibody produced in rabbit	Sigma-Aldrich SAB4500003 Anti-BCL-2 antibody produced in rabbit	Sigma-Aldrich SAB4300339 Anti-BCL2 (Ab-56) antibody produced in rabbit
description clone Bcl-2-100, ascites fluid	description affinity isolated antibody	description affinity isolated antibody	description affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... BCL2(596)	Gene Information human ... BCL2(596)	Gene Information human ... BCL2(596)	Gene Information human ... BCL2(596)
clone Bcl-2-100, monoclonal	clone polyclonal	clone polyclonal	clone polyclonal
species reactivity human	species reactivity human	species reactivity rat, mouse, human	species reactivity human
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
antibody form ascites fluid	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody

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10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c