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B3251

Berberine chloride form

Synonym(s):

Benzodioxide, Berberine HCl, Natural Yellow 18

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Size/SKUAvailabilityPrice
5 g
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$68.50
10 g
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$131.00
25 g
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$274.00

About This Item

Empirical Formula (Hill Notation):
C20H18ClNO4
CAS Number:
Molecular Weight:
371.81
EC Number:
211-195-9
UNSPSC Code:
12171500
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Colour Index Number:
75160
Beilstein/REAXYS Number:
3836585
Form:
powder

$68.50


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form

powder

Quality Segment

solubility

methanol: soluble

SMILES string

COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]

InChI

1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

InChI key

VKJGBAJNNALVAV-UHFFFAOYSA-M

General description

Berberine Chloride form or Natural Yellow 18, is also known as 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium is a benzyl tetra isoquinoline plant alkaloid. Berberine contains a quaternary base and is commercially available in berberine chloride form.

Application

Berberine Chloride is a fluorescent stain used to stain heparin in mast cells. Berberine upregulates the expression of Pgp in hepatoma cells.
Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

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This Item
00900585140501065210
description

-

description

primary reference standard

description

technical, ≥90% (AT)

description

United States Pharmacopeia (USP) Reference Standard

form

powder

form

-

form

powder

form

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

-

solubility

methanol: soluble

solubility

-

solubility

-

solubility

-


Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

  1. I want to ask you about this compound whether it is API. And what is the purity percentage. Further. I want to inquire about this compound. Is it same berberine hydrochloride

    1 answer
    1. B3251 is a laboratory research grade product. It has two purity specifications, Titration by perchloric acid with a purity specification of 97 - 102 % and a TLC purity with a specification of ≥ 98 %. The CAS number for B3251 - Berberine chloride form is synonymous with Benzodioxide, Berberine HCl, Natural Yellow 18.

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