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Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse

Name: Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse
Brand: SIGMA

clone 74219.11, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-BMP-6

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD01321772

Conjugate:

unconjugated

Clone:

74219.11, monoclonal

Application:

ELISA (c), Neutral, WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

74219.11, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

capture ELISA: suitable, neutralization: suitable, western blot: 1-2 μg/mL

isotype

IgG2b

UniProt accession no.

P22004

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BMP6(654)

Description

General description

Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP-6 regulates both T cell and B cell-mediated immunity. It acts through Smad and p38 pathway to induce the expression of IL-6. Additionally, it induces the expression of iNOS by macrophages through the activation of NF-κB and STAT pathways. BMP-6 is a stimulator of differentiation of liver, bone, neuronal tissue and embryonic kidney and urinary systems. Studies also indicate that BMP-6 is important in the regulation of liver hormone, hepcidin, expression that is important to maintain systemic iron balance
Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7.

Immunogen

recombinant human BMP-6.

Application

Anti-Bone Morphogenetic Protein 6 antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. For capture ELISA a concentration of 4 μg/ml is recommemnded. The antibody is also suitable for neutralization reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	B3805	WH0000653M2	SAB1412426
Sigma-Aldrich B3680 Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse	Sigma-Aldrich B3805 Anti-Bone Morphogenetic Protein 5 antibody produced in goat	Sigma-Aldrich WH0000653M2 Monoclonal Anti-BMP5 antibody produced in mouse	Sigma-Aldrich SAB1412426 ANTI-BMP5 antibody produced in mouse
description clone 74219.11, purified immunoglobulin, lyophilized powder	description affinity isolated antibody, lyophilized powder	description clone 1C1, purified immunoglobulin, buffered aqueous solution	description clone 4B3, purified immunoglobulin, buffered aqueous solution
clone 74219.11, monoclonal	clone polyclonal	clone 1C1, monoclonal	clone 4B3, monoclonal
biological source mouse	biological source goat	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... BMP6(654)	Gene Information human ... BMP5(653)	Gene Information human ... BMP5(653)	Gene Information human ... BMP5(653)
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
species reactivity human	species reactivity human	species reactivity human	species reactivity human

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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