Key Documents

BAY U6751 hydrate

Name: BAY U6751 hydrate
Brand: SIGMA
Price: 282 USD
Availability: InStock

solid, ≥98% (HPLC)

Synonym(s):

4-(2-Chlorophenyl)-1-ethyl-1,4-dihydro-6-methyl-2,3,5-pyridinetricarboxylic acid 5-isopropyl ester disodium salt hydrate

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Size/SKU	Availability	Price
5 mg	Check Cart for Availability	$282.00
25 mg	Check Cart for Availability	$866.00

About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₀ClNNa₂O₆ · xH₂O

CAS Number:

114290-51-6

Molecular Weight:

451.81 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24891730

UNSPSC Code:

12352200

MDL number:

MFCD08705410

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

protect from light

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

solubility

H₂O: >8 mg/mL

originator

Bayer

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[H]O[H].CCN1C(C)=C(C(c2ccccc2Cl)C(C([O-])=O)=C1C([O-])=O)C(=O)OC(C)C

InChI

1S/C20H22ClNO6.2Na.H2O/c1-5-22-11(4)14(20(27)28-10(2)3)15(12-8-6-7-9-13(12)21)16(18(23)24)17(22)19(25)26;;;/h6-10,15H,5H2,1-4H3,(H,23,24)(H,25,26);;;1H2/q;2*+1;/p-2

InChI key

QECLOEJXLYHXNF-UHFFFAOYSA-L

Description

Biochem/physiol Actions

BAY U6751 is a glycogen phosphorylase inhibitor. Formed from the prodrug, BAYR3401. BAY U6751 exists as the enantiomeric mixture. BAY W1807 is the active metabolite.

BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen phosphorylase a and b. In gel-filtered liver extracts, racemic BAY U6751 (containing active BAY W1807) was tested for inhibition of phosphorylase in the glycogenolytic (in which only phosphorylase a is active). In liver extracts, BAY U6751 (0.9-36 μmol/L) inhibited glycogen synthesis by phosphorylase b (notwithstanding the inclusion of AMP), but not by phosphorylase a. Inhibition of phosphorylase-a-catalyzed glycogenolysis was partially relieved by AMP (500 μmol/L). BAY U6751 facilitated phosphorylase-a dephosphorylation. Isolated hepatocytes and perfused livers were tested for BAY R3401-induced changes in phosphorylase-a:b ratios and glycogenolytic output.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Light sensitive. Store in amber vials.

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This Item	B3561	B9685	SML0005
Sigma-Aldrich B3686 BAY U6751 hydrate	Sigma-Aldrich B3561 BAY 73-6691	Sigma-Aldrich B9685 BAY 61-3606 hydrochloride hydrate	Sigma-Aldrich SML0005 Cerivastatin sodium salt hydrate
description solid, ≥98% (HPLC)	description ≥98% (HPLC), powder	description ≥98% (HPLC), powder	description ≥98% (HPLC)
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: >8 mg/mL	solubility DMSO: >20 mg/mL	solubility H₂O: soluble	solubility H₂O: ≥5 mg/mL
storage condition protect from light	storage condition -	storage condition desiccated	storage condition desiccated

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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