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B3795

Brain-derived neurotrophic factor human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

Abrineurin, BDNF

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A voi/SKUDisponibilitàPrezzo
5 μg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
393,00 €
10 μg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
521,00 €

Informazioni su questo articolo

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00285579
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
~27 kDa
Impurities:
≤1.00 EU/μg Endotoxin level

393,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Nome del prodotto

Brain-derived neurotrophic factor human, BDNF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Segment

200

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized powder

quality

endotoxin tested

mol wt

~27 kDa

packaging

pkg of 10 μg, pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

≤1.00 EU/μg Endotoxin level

UniProt accession no.

P23560

storage temp.

−20°C

General description

BDNF is a member of the neurotrophin family of growth factors that includes NGF, NT-3, and NT-4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells.1 BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non-neuronal cells.
The active form of BDNF recombinant human protein (27 kDa) is a dimer formed by two identical 119 amino acid subunits held together by strong hydrophobic interactions

Application

Brain-derived neurotrophic factor (BDNF) recombinant human protein has been used as a supplement in various types of culture media.[1][2][3]

Biochem/physiol Actions

Brain-derived neurotrophic factor (BDNF) is a 13.6 kDa (or 27.2 kDa dimer) member of the neurotrophin family. BDNF has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. BDNF is important in development and maintenance of neuronal populations within the central nervous system or cells directly associated with it. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells.

Physical form

lyophilized from a sterile 0.2 μm filtered solution with BSA

Analysis Note

The biological activity is determined by its ability to stimulate the proliferation of human neuroblastoma cells, SH-SY5Y.

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Brain-derived neurotrophic factor human BDNF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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BDNF human Carrier free, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), suitable for cell culture

Sigma-Aldrich

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Glial Cell Line-derived Neurotrophic Factor human recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

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Glial Cell Line-derived Neurotrophic Factor human

ProBDNF human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sigma-Aldrich

SRP6053

ProBDNF human

description

BDNF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

Carrier free, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), suitable for cell culture

description

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

-

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

biological source

human

biological source

human

biological source

human

biological source

human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

form

lyophilized powder

form

lyophilized

form

lyophilized powder

form

lyophilized

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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