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B5188

Butenafine hydrochloride

≥98% (HPLC)

Synonym(s):

Butenafine hydrochloride, Mentax, N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride, N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine hydrochloride

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10 mg

Available to ship TODAYfromMILWAUKEE

$85.80
$72.93
50 mg

Available to ship TODAYfromMILWAUKEE

$324.00

About This Item

Empirical Formula (Hill Notation):
C23H27N · HCl
CAS Number:
101827-46-7
Molecular Weight:
353.93
NACRES:
NA.77
PubChem Substance ID:
329773252
UNSPSC Code:
51111800
MDL number:
MFCD00917064
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥10 mg/mL

originator

Schering Plough

storage temp.

room temp

SMILES string

Cl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23

InChI

1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H

InChI key

LJBSAUIFGPSHCN-UHFFFAOYSA-N

General description

Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.

Application

Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.

Biochem/physiol Actions

Butenafine exhibits fungicidal and antimycotic activity. This fungal squalene epoxidase inhibitor serves as an effective fungicide against T. rubrum, T. mentagrophytes, Microsporum canis, Aspergillus fumigatus, Sporothrix schenckii, Candida parapsilosis, and C. albicans. It is considered more effective and rapid than other antifungal drugs at curing dermatophytosis and preventing recurrences. In humans, it is used topically to treat tinea conditions and superficial candidiasis. Butenafine is considered a promising antimycotic compound to treat tinea pedis due to its efficiency, safety profile, relapse rates, and cost-effectiveness.
Butenafine is an antifungal; squalene epoxidase inhibitor. It inhibits the synthesis of ergosterol needed in fungal cell membranes.
Butenafine possesses antifungal property. It is a squalene epoxidase inhibitor. Butenafine can inhibit the synthesis of ergosterol needed in fungal cell membranes.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Butenafine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

B5188

Butenafine hydrochloride

(±)-Mepivacaine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1444

(±)-Mepivacaine hydrochloride

ORG 25543 Hydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML2417

ORG 25543 Hydrochloride

Lorcainide hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1025

Lorcainide hydrochloride

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

solubility

DMSO: ≥10 mg/mL

solubility

H2O: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 10 mg/mL, clear

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H312

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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