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Anti-Bak antibody produced in rabbit

Name: Anti-Bak antibody produced in rabbit
Brand: SIGMA
Price: 589.05 EUR

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Bcl-2 Homologous Antagonist/Killer

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Size/SKU	Availability	Price
0.2 mL	Please contact Customer Service for Availability	€693.00 €589.05

About This Item

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00282578

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (p), WB

Citations:

€589.05

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 28 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using sections of human colon carcinoma, microarray: suitable, western blot: 1:2,000 using human epidermal carcinoma A431 whole cell extract

UniProt accession no.

Q16611

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BAK1(578)

Description

General description

Bak (Bcl-2 homologous antagonist/killer, Bak1) belongs to the B-cell lymphoma 2 (Bcl-2) family of proteins. The bak gene is mapped to chromosome 6 and encodes a 233 amino acid protein with a predicted MW of 23.4 kDa. Bak shares homology with Bcl-2 in the Bcl‐2 homology (BH) domains (BH1 and BH2). Bak is expressed in a wide variety of cell types and tissues, with the highest levels observed in heart and skeletal muscle.

Immunogen

synthetic peptide corresponding to the N-terminus of human Bak amino acids 23-38 with C-terminally added lysine, conjugated to KLH.

Application

Anti-Bak antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.[1]

Biochem/physiol Actions

Bak (Bcl-2 homologous antagonist/killer, Bak1) is involved in regulating apoptosis. Bak can accelerate the rate of apoptosis when overexpressed in some cell lines. Increased Bak expression in normal and neoplastic intestinal epithelial cells results in apoptosis. However, expression of Bak in a human lymphoblastoid cell line, provided protection from apoptosis induced by serum deprivation and the oxidant menadione, suggesting that the function of Bak may be context dependent.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4502532	HPA001198	HPA007932
$Anti-Bak antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich B5897 Anti-Bak antibody produced in rabbit	Sigma-Aldrich SAB4502532 Anti-BAK antibody produced in rabbit	Sigma-Aldrich HPA001198 Anti-BTK antibody produced in rabbit	Sigma-Aldrich HPA007932 Anti-CDK7 antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
species reactivity human	species reactivity human, mouse	species reactivity human	species reactivity human
UniProt accession no. Q16611	UniProt accession no. Q16611	UniProt accession no. Q06187	UniProt accession no. P50613

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c