Skip to Content
MilliporeSigma

Skip To

B6542

Brefeldin A

≥99% (HPLC and TLC), BioXtra, Molecular Biology

Brefeldin A

Synonym(s):

γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$232.00
25 mg
Check Cart for Availability
$750.00

About This Item

Empirical Formula (Hill Notation):
C16H24O4
CAS Number:
Molecular Weight:
280.36
UNSPSC Code:
12352200
NACRES:
NA.52
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
25191
Assay:
≥99% (HPLC and TLC)
Form:
powder

$232.00


Available to ship TODAYDetails


Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


biological source

Penicillium brefeldianum

Quality Segment

grade

Molecular Biology

product line

BioXtra

assay

≥99% (HPLC and TLC)

form

powder

mol wt

280.36

solubility

DMSO: 10 mg/mL (Store stock solutions at -20 °C)

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1

InChI

1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

InChI key

KQNZDYYTLMIZCT-KQPMLPITSA-N

General description

Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.
Chemical structure: macrolide

Application

Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport

Biochem/physiol Actions

Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Disrupts the structure and function of the Golgi apparatus; activator of the sphingomyelin cycle.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
B7651203729B5936
description

≥99% (HPLC and TLC), BioXtra, Molecular Biology

description

from Penicillium brefeldianum, ≥99% (HPLC and TLC)

description

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function.

description

Ready Made Solution, from Penicillium brefeldianum, 10 mg/mL in DMSO

form

powder

form

powder

form

crystalline solid

form

ready-to-use solution

assay

≥99% (HPLC and TLC)

assay

≥99% (HPLC and TLC)

assay

≥95% (HPLC)

assay

-

Quality Level

300

Quality Level

300

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

mol wt

280.36

mol wt

-

mol wt

-

mol wt

-

solubility

DMSO: 10 mg/mL (Store stock solutions at -20 °C)

solubility

DMSO: 10 mg/mL

solubility

methanol: 2 mg/mL

solubility

DMSO: 10 mg/mL


Still not finding the right product?

Explore all of our products under Brefeldin A


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

Active Filters

  1. 1 Ratings-Only Review