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Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse

Name: Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse
Brand: SIGMA
Price: 831 CAD

~1 mg/mL, clone 28F3, purified immunoglobulin, buffered aqueous glycerol solution

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Pack Size	SKU	Availability	Price
0.1 mg		Please contact Customer Service for Availability	$831.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01864149

Conjugate:

unconjugated

Clone:

28F3, monoclonal

Application:

IP, WB

Citations:

$831.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

28F3, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen 28-30 kDa

species reactivity

bovine, human

concentration

~1 mg/mL

technique(s)

immunoprecipitation (IP): suitable, western blot: 1:5,000 using normal human fibroblasts or MDBK cells

isotype

IgG1

UniProt accession no.

Q96L46

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CAPNS1(826), CAPNS2(84290)

Description

General description

Calpain small subunit 1 (Capns1) is a small regulatory subunit associated with the μ-calpain (calpain 1) and m-calpain (calpain 2). The CAPNS1 gene is mapped to human chromosome 19q13.12.

Immunogen

purified calpain from human placenta.

Application

Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse has been used in immunoprecipitation and immunoblotting.

Biochem/physiol Actions

Calpain small subunit 1 (Capns1) participates in the actin cytoskeleton rearrangement and cell migration events. It is crucial for embryonic development. Capns1 interacts with the Ras GTPase activating protein Src homology 3 domain (SH3) (RasGAP-SH3) domain to regulate cell migration and cell survival. It is essential for calpain activity. Capns1 is associated with the oncogenesis of many tumor types including hepatocellular, colorectal, ovarian, and breast cancer.

Physical form

Solution in 0.02 M sodium phosphate, pH 7.5, and 0.15 M sodium chloride containing 50% glycerol and 3 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	C0355	WH0000826M1	C268
Sigma-Aldrich C0230 Monoclonal Anti-m/μ Calpain, Small Subunit antibody produced in mouse	Sigma-Aldrich C0355 Monoclonal Anti-μ-Calpain, Large Subunit antibody produced in mouse	Sigma-Aldrich WH0000826M1 Monoclonal Anti-CAPNS1 antibody produced in mouse	Sigma-Aldrich C268 Monoclonal Anti-m-Calpain (Domain III/IV) antibody produced in mouse
species reactivity bovine, human	species reactivity rat, mouse, human, bovine	species reactivity rat, mouse, human	species reactivity pig, human, rat, bovine
clone 28F3, monoclonal	clone 15C10, monoclonal	clone 3C4, monoclonal	clone 107-82, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... CAPNS1(826), CAPNS2(84290)	Gene Information human ... CAPN1(823) mouse ... Capn1(12333)	Gene Information human ... CAPNS1(826)	Gene Information human ... CAPN2(824) rat ... Capn2(29154)
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form ascites fluid

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Global Trade Item Number

SKU	GTIN
C0230-.1MG	04061837896569

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