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C0730

Anti-CD137 antibody produced in goat

Name: Anti-CD137 antibody produced in goat
Brand: SIGMA
Price: 932278 KRW

affinity isolated antibody, lyophilized powder

동의어(들):

Anti-4-1BB

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

보기 변경

팩 크기/SKU	재고 정보	가격 (VAT 별도)
0.1 mg	구입 가능 여부는 고객센터에 문의하십시오.	₩932,278

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01094424

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (c), FACS, ICC, WB

Citations:

₩932,278

구입 가능 여부는 고객센터에 문의하십시오.

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도움 문의

속성

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

capture ELISA: 0.2-0.8 μg/mL, flow cytometry: 2.5 μg using 10⁶ human T cells treated with PHA, immunocytochemistry: 5-15 μg/mL, western blot: 0.1 μg/mL

impurities

<0.10 EU/μg endotoxin

UniProt accession no.

Q07011

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TNFRSF9(3604)

설명

General description

CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes.

Immunogen

mouse myeloma cell line NS0-derived recombinant human 41BB/TNFRSF9/CD137 Leu²⁴Gln¹⁸⁶

Application

Anti-CD137 antibody produced in goat is suitable for the following applications:

Agonist Activity: Measured by its ability to costimulate IFNg secretion by human T cells in the presence of anti-CD3. The ED50 for this effect is typically 5-20μg/mL.
ELISA capture: It can be used as a capturing reagent in a human 4-1BB sandwich immunoassay in combination with biotinylated human 4-1BB detection antibody and recombinant human 4-1BB as the standard. The suggested coating concentration range is 0.2-0.8μg/ml. The recommended concentration of the detection antibody is 0.1-0.4μg/mL.
Flow cytometry: 2.5μg/106 cells using Human T cells treated with PHA (phytohemagglutinin).
Immunoblotting: A working concentration of 0.1μg/ml was determined using recombinant human CD137.
Immunocytochemistry: 5-15μg/mL using immersion fixed human peripheral blood mononuclear cells.

Biochem/physiol Actions

CD137 in T lymphocytes helps to regulate activation, proliferation and apoptosis. CD137 and CD28 are co-stimulatory molecules of T cell activation. It plays an important role in regulating T-cell-dependent immune responses. The expression of CD137 correlates negatively with lymphocyte proliferation and induces cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and helps in prolongs survival.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Reconstitute at 0.2 mg/mL in sterile PBS

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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차이점 표시

1 of 1

이 품목	SAB4700791	SAB4701068	HPA071425
Sigma-Aldrich C0730 Anti-CD137 antibody produced in goat	Sigma-Aldrich SAB4700791 Monoclonal Anti-CD137 antibody produced in mouse	Sigma-Aldrich SAB4701068 Monoclonal Anti-CD137-APC antibody produced in mouse	Sigma-Aldrich HPA071425 Anti-TNFRSF9 antibody produced in rabbit
description affinity isolated antibody, lyophilized powder	description clone 4B4-1	description clone 4B4-1	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form affinity isolated antibody
biological source goat	biological source mouse	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate Allophycocyanin conjugate	conjugate unconjugated
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
form lyophilized powder	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution
Gene Information human ... TNFRSF9(3604)	Gene Information human ... TNFRSF9(3604)	Gene Information human ... TNFRSF9(3604)	Gene Information human ... TNFRSF9(3604)

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저장 등급

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c